A small family of S-DABO cytosine analogs (S-DABOCs) has been synthesized and biologically evaluated as HIV-1 inhibitor both on wild type (wt) and drug-resistant mutants leading to the identification of an interesting compound (5d). Molecular modeling studies have been finally performed in order to rationalize the results.
Botta, M., Angeli, L., Franchi, L., Contemori, L., Maga, G., Samuele, A., et al. (2008). Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18, 5777-5780 [10.1016/j.bmcl.2008.09.070].
Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies.
BOTTA, MAURIZIO;ANGELI, LUCILLA;FRANCHI, LUIGI;CONTEMORI, LORENZO;
2008-01-01
Abstract
A small family of S-DABO cytosine analogs (S-DABOCs) has been synthesized and biologically evaluated as HIV-1 inhibitor both on wild type (wt) and drug-resistant mutants leading to the identification of an interesting compound (5d). Molecular modeling studies have been finally performed in order to rationalize the results.
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https://hdl.handle.net/11365/9414
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