The aim of this study was to characterize the responsiveness of CYP1A and ABC transport proteins in European Sea bass (Dicentrarchus labrax) waterborne exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) (46 pg/L) for 24 h and 7 days. Genes modulation (abcb1, abcc1-2, cyp1a), EROD activity were investigated in liver and 2,3,7,8-TCDD bioconcentration in liver and muscle. TCDD induced significantly cyp1a gene expression and EROD activity at 24 h and 7 d. A significant up-regulation of abcb1 was also observed but only after 7 days. No modulation of abcc1 and abcc2 genes was observed. Waterborne TCDD exposure was able to induce CYP1A and abcb1 encoding for P-glycoprotein in juvenile of European sea bass. (C) 2014 Elsevier Ltd. All rights reserved.

Della Torre, C., Mariottini, M., Vannuccini, M.L., Trisciani, A., Marchi, D., & Corsi, I. (2014). Induction of CYP1A and ABC transporters in European sea bass Dicentrarchus labrax upon 2,3,7,8-TCDD waterborne exposure. MARINE ENVIRONMENTAL RESEARCH, 99, 218-222 [10.1016/j.marenvres.2014.06.009].

Induction of CYP1A and ABC transporters in European sea bass Dicentrarchus labrax upon 2,3,7,8-TCDD waterborne exposure

Mariottini, M.;Vannuccini, M. L.;Trisciani, A.;Corsi, I.
2014

Abstract

The aim of this study was to characterize the responsiveness of CYP1A and ABC transport proteins in European Sea bass (Dicentrarchus labrax) waterborne exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) (46 pg/L) for 24 h and 7 days. Genes modulation (abcb1, abcc1-2, cyp1a), EROD activity were investigated in liver and 2,3,7,8-TCDD bioconcentration in liver and muscle. TCDD induced significantly cyp1a gene expression and EROD activity at 24 h and 7 d. A significant up-regulation of abcb1 was also observed but only after 7 days. No modulation of abcc1 and abcc2 genes was observed. Waterborne TCDD exposure was able to induce CYP1A and abcb1 encoding for P-glycoprotein in juvenile of European sea bass. (C) 2014 Elsevier Ltd. All rights reserved.
Della Torre, C., Mariottini, M., Vannuccini, M.L., Trisciani, A., Marchi, D., & Corsi, I. (2014). Induction of CYP1A and ABC transporters in European sea bass Dicentrarchus labrax upon 2,3,7,8-TCDD waterborne exposure. MARINE ENVIRONMENTAL RESEARCH, 99, 218-222 [10.1016/j.marenvres.2014.06.009].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/49104
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