The aim of this study was to characterize the responsiveness of CYP1A and ABC transport proteins in European Sea bass (Dicentrarchus labrax) waterborne exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) (46 pg/L) for 24 h and 7 days. Genes modulation (abcb1, abcc1-2, cyp1a), EROD activity were investigated in liver and 2,3,7,8-TCDD bioconcentration in liver and muscle. TCDD induced significantly cyp1a gene expression and EROD activity at 24 h and 7 d. A significant up-regulation of abcb1 was also observed but only after 7 days. No modulation of abcc1 and abcc2 genes was observed. Waterborne TCDD exposure was able to induce CYP1A and abcb1 encoding for P-glycoprotein in juvenile of European sea bass. (C) 2014 Elsevier Ltd. All rights reserved.
Della Torre, C., Mariottini, M., Vannuccini, M.L., Trisciani, A., Marchi, D., Corsi, I. (2014). Induction of CYP1A and ABC transporters in European sea bass Dicentrarchus labrax upon 2,3,7,8-TCDD waterborne exposure. MARINE ENVIRONMENTAL RESEARCH, 99, 218-222 [10.1016/j.marenvres.2014.06.009].
Induction of CYP1A and ABC transporters in European sea bass Dicentrarchus labrax upon 2,3,7,8-TCDD waterborne exposure
Mariottini, M.;Vannuccini, M. L.;Trisciani, A.;Corsi, I.
2014-01-01
Abstract
The aim of this study was to characterize the responsiveness of CYP1A and ABC transport proteins in European Sea bass (Dicentrarchus labrax) waterborne exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) (46 pg/L) for 24 h and 7 days. Genes modulation (abcb1, abcc1-2, cyp1a), EROD activity were investigated in liver and 2,3,7,8-TCDD bioconcentration in liver and muscle. TCDD induced significantly cyp1a gene expression and EROD activity at 24 h and 7 d. A significant up-regulation of abcb1 was also observed but only after 7 days. No modulation of abcc1 and abcc2 genes was observed. Waterborne TCDD exposure was able to induce CYP1A and abcb1 encoding for P-glycoprotein in juvenile of European sea bass. (C) 2014 Elsevier Ltd. All rights reserved.
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https://hdl.handle.net/11365/49104
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