The Mycobacterium tuberculosis extracellular zinc metalloprotease 1 (Zmp1) has been proposed to play a key role in phagosome maturation and to enhance the survival of Mycobacterium tuberculosis in the host. Consequently, small molecule inhibitors of Zmp1 are of pivotal importance as a tool to better understand the pathogenicity of Zmp1 and as lead candidates for pharmacological intervention. Here we combined in silico structure-based inhibitor design with biochemical studies to discover and characterize the first potent competitive Zmp1 inhibitor showing a Ki of 94nM and a high selectivity for Zmp1 with respect to human Neprilysin.
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|Titolo:||Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor.|
|Citazione:||Mori, M., Moraca, F., Deodato, D., Ferraris, D.m., Selchow, P., Sander, P., et al. (2014). Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 24(11), 2508-2511.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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