Dose-dependent water exchange times and intracellular water contents were measured by NMR (nuclear magnetic resonance) in erythrocytes and mitochondria interacted with the anti-anginal and anti-arrhytmic agent, amiodarone. Addition of the drug up to 26 microM yielded 80% enhancement of the water exchange rate in erythrocytes at 37 degrees C and 41% enhancement at 22 degrees C with 40% and 9%, respectively, increases in the intracellular water content. Similar enhancements were obtained in mitochondria at 22 degrees C. The data suggests a somewhat higher affinity of amiodarone to mitochondrial than to erythrocyte membranes.
Federico, A., Battisti, C., Manneschi, L., Gaggelli, E., Tassini, M., Valensin, G., et al. (1996). Amiodarone affects membrane water permeability properties of human erythrocytes and rat mitochondria. EUROPEAN JOURNAL OF PHARMACOLOGY, 304(1-3), 237-241 [10.1016/0014-2999(96)00148-3].
Amiodarone affects membrane water permeability properties of human erythrocytes and rat mitochondria.
FEDERICO, ANTONIO;BATTISTI, CARLA;TASSINI, MARIA;VIVI, ANTONIO
1996-01-01
Abstract
Dose-dependent water exchange times and intracellular water contents were measured by NMR (nuclear magnetic resonance) in erythrocytes and mitochondria interacted with the anti-anginal and anti-arrhytmic agent, amiodarone. Addition of the drug up to 26 microM yielded 80% enhancement of the water exchange rate in erythrocytes at 37 degrees C and 41% enhancement at 22 degrees C with 40% and 9%, respectively, increases in the intracellular water content. Similar enhancements were obtained in mitochondria at 22 degrees C. The data suggests a somewhat higher affinity of amiodarone to mitochondrial than to erythrocyte membranes.
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https://hdl.handle.net/11365/28792
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