Myasthenia gravis and mitochondrial myopathy may present with similar clinical symptoms as inconstant palpebral ptosis, ophthalmoparesis, and muscle weakness. A few case initially diagnosed as myasthenia gravis by a positive decremental response on EMG and successful anticholinesterase therapy revealed to be affected by mitochondrial disease. We report a new case initially found to be affected by myasthenia gravis in whom muscle biopsy, performed because of symptom worsening, disclosed a mitochondrial myopathy. It is not clear if the association of mitochondrial myopathy and myasthenia gravis is coincidental or if there is a pathogenic link between the two pathologies. We suggest that muscle biopsy should be performed in cases with atypical myasthenia gravis signs.

Plewnia, K., Dotti, M., Malandrini, A., Manneschi, L., Battisti, C., DE STEFANO, N., et al. (1997). A rare association of myasthenia gravis and mitochondrial myopathy: a clinical, biochemical and morphologic study of one case. JOURNAL OF SUBMICROSCOPIC CYTOLOGY AND PATHOLOGY, 29(3), 335-338.

A rare association of myasthenia gravis and mitochondrial myopathy: a clinical, biochemical and morphologic study of one case

DOTTI, MARIA;MALANDRINI, ALESSANDRO;BATTISTI, CARLA;DE STEFANO, NICOLA;RUFA, ALESSANDRA;MOTOLESE, EDUARDO;FEDERICO, ANTONIO
1997-01-01

Abstract

Myasthenia gravis and mitochondrial myopathy may present with similar clinical symptoms as inconstant palpebral ptosis, ophthalmoparesis, and muscle weakness. A few case initially diagnosed as myasthenia gravis by a positive decremental response on EMG and successful anticholinesterase therapy revealed to be affected by mitochondrial disease. We report a new case initially found to be affected by myasthenia gravis in whom muscle biopsy, performed because of symptom worsening, disclosed a mitochondrial myopathy. It is not clear if the association of mitochondrial myopathy and myasthenia gravis is coincidental or if there is a pathogenic link between the two pathologies. We suggest that muscle biopsy should be performed in cases with atypical myasthenia gravis signs.
Plewnia, K., Dotti, M., Malandrini, A., Manneschi, L., Battisti, C., DE STEFANO, N., et al. (1997). A rare association of myasthenia gravis and mitochondrial myopathy: a clinical, biochemical and morphologic study of one case. JOURNAL OF SUBMICROSCOPIC CYTOLOGY AND PATHOLOGY, 29(3), 335-338.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/23327
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