Based upon synthetic and biochemical results, a novel and potent tacrine analogue and heterobivalent analogues of tacrine, were designed. The role played by the amino groups of homo- and heterobivalent ligands in the interaction with the peripheral and catalytic sites of AChE and BuChE were investigated. The syntheses of these materials together with the results of AChE/BuChE inhibition assays are detailed. © 2001 Elsevier Science Ltd.
Savini, L., Campiani, G., Gaeta, A., Pellerano, C., Fattorusso, C., Chiasserini, L., et al. (2001). Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 11(13), 1779-1782 [10.1016/S0960-894X(01)00294-3,].
Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase
Savini, Luisa;Campiani, Giuseppe;Pellerano, Cesare;Chiasserini, Luisa;
2001-01-01
Abstract
Based upon synthetic and biochemical results, a novel and potent tacrine analogue and heterobivalent analogues of tacrine, were designed. The role played by the amino groups of homo- and heterobivalent ligands in the interaction with the peripheral and catalytic sites of AChE and BuChE were investigated. The syntheses of these materials together with the results of AChE/BuChE inhibition assays are detailed. © 2001 Elsevier Science Ltd.
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https://hdl.handle.net/11365/19230
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