Two methyl end-capped oligo(ethylene glycol) esters (1a,b) of benzofulvene derivative BF1 were synthesized and induced to polymerize spontaneously by solvent removal to give poly-la,b showing both NMR and absorption/emission spectra very similar to those of poly-BF1. Poly-la,b showed relatively high molecular weight and the tendency to depolymerize to a different degree as a function of the temperature in the presence of solvents, while they exhibited appreciable stability in the absence of solvent. Poly-1b, bearing a longer oligo(ethylene glycol) side chain, featured an amphiphilic character and interacted with a number of organic solvents to produce transparent gel aggregates, and with water to give a quite compact physical gel. Rheological studies performed on the hydrogel suggested strong get characteristics and the combination of rheology and NMR transverse relaxation measurements allowed the pore size distribution in the hydrogel to be defined. Finally, biological studies performed with poly-1b solutions showed neither cytotoxicity nor cell viability impairment Suggesting potential biocompatibility features for this polymer. In conclusion, poly-1b can be considered a promising polymer for the preparation of hydrogels potentially useful in a range of biological and biotechnological applications such as drug delivery, molecular recognition, biosensing, protein and DNA separation, micro- and nanofluidics, as well as tissue engineering.

Cappelli, A., Galeazzi, S., Giuliani, G., Anzini, M., Grassi, M., Lapasin, R., et al. (2009). Synthesis and Spontaneous Polymerization of Oligo(ethylene glycol)-Conjugated Benzofulvene Macromonomers. A Polymer Brush Forming a Physical Hydrogel. MACROMOLECULES, 42(7), 2368-2378 [10.1021/ma802429g].

Synthesis and Spontaneous Polymerization of Oligo(ethylene glycol)-Conjugated Benzofulvene Macromonomers. A Polymer Brush Forming a Physical Hydrogel

Cappelli, Andrea;Giuliani, Germano;Anzini, Maurizio;Donati, Alessandro;Vomero, Salvatore
2009-01-01

Abstract

Two methyl end-capped oligo(ethylene glycol) esters (1a,b) of benzofulvene derivative BF1 were synthesized and induced to polymerize spontaneously by solvent removal to give poly-la,b showing both NMR and absorption/emission spectra very similar to those of poly-BF1. Poly-la,b showed relatively high molecular weight and the tendency to depolymerize to a different degree as a function of the temperature in the presence of solvents, while they exhibited appreciable stability in the absence of solvent. Poly-1b, bearing a longer oligo(ethylene glycol) side chain, featured an amphiphilic character and interacted with a number of organic solvents to produce transparent gel aggregates, and with water to give a quite compact physical gel. Rheological studies performed on the hydrogel suggested strong get characteristics and the combination of rheology and NMR transverse relaxation measurements allowed the pore size distribution in the hydrogel to be defined. Finally, biological studies performed with poly-1b solutions showed neither cytotoxicity nor cell viability impairment Suggesting potential biocompatibility features for this polymer. In conclusion, poly-1b can be considered a promising polymer for the preparation of hydrogels potentially useful in a range of biological and biotechnological applications such as drug delivery, molecular recognition, biosensing, protein and DNA separation, micro- and nanofluidics, as well as tissue engineering.
2009
Cappelli, A., Galeazzi, S., Giuliani, G., Anzini, M., Grassi, M., Lapasin, R., et al. (2009). Synthesis and Spontaneous Polymerization of Oligo(ethylene glycol)-Conjugated Benzofulvene Macromonomers. A Polymer Brush Forming a Physical Hydrogel. MACROMOLECULES, 42(7), 2368-2378 [10.1021/ma802429g].
File in questo prodotto:
File Dimensione Formato  
ma802429g.pdf

non disponibili

Tipologia: Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 1.62 MB
Formato Adobe PDF
1.62 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/18986
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo