The susceptibility of human leukocyte (alpha), fibroblast (beta) and recombinant alpha-2-interferons to clearance by the isolated and perfused rabbit liver has been evaluated. Human leukocyte and recombinant alpha-2-interferons were stable and their initial levels were maintained in the perfusate even if they had been treated with neuraminidase, thus suggesting that alpha-interferons have no exposed sugars recognizable by hepatic binding proteins. On the other hand, native, and particularly desialylated human beta-interferon, underwent marked hepatic uptake confirming the importance of the liver as a catabolic site for glycosylated interferons.

Bocci, V., Pacini, A., Bandinelli, L., Pessina, G.p., Muscettola, M., Ricci, L. (1982). The role of liver in the catabolism of human alpha- and beta-interferon. JOURNAL OF GENERAL VIROLOGY, 60(2), 397-400 [10.1099/0022-1317-60-2-397].

The role of liver in the catabolism of human alpha- and beta-interferon.

PACINI A;PESSINA GP;M. MUSCETTOLA;RICCI L
1982-01-01

Abstract

The susceptibility of human leukocyte (alpha), fibroblast (beta) and recombinant alpha-2-interferons to clearance by the isolated and perfused rabbit liver has been evaluated. Human leukocyte and recombinant alpha-2-interferons were stable and their initial levels were maintained in the perfusate even if they had been treated with neuraminidase, thus suggesting that alpha-interferons have no exposed sugars recognizable by hepatic binding proteins. On the other hand, native, and particularly desialylated human beta-interferon, underwent marked hepatic uptake confirming the importance of the liver as a catabolic site for glycosylated interferons.
Bocci, V., Pacini, A., Bandinelli, L., Pessina, G.p., Muscettola, M., Ricci, L. (1982). The role of liver in the catabolism of human alpha- and beta-interferon. JOURNAL OF GENERAL VIROLOGY, 60(2), 397-400 [10.1099/0022-1317-60-2-397].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/17195
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