Oleuropein has several beneficial properties. Strong evidences of its role in preventing osteoarthritis and playing analgesic and sedative effects are gaining. Starting from that, we entrapped a vegetal bioactive matrix rich in oleuropein into calcium ions crosslinked gellan gum and hyaluronan formulations. Infrared spectroscopy and thermal analysis confirmed the absence of significant interactions between the polysaccharide shells and the bioactive matrix, thus guaranteeing a burst release of oleuropein. The adequate mechanical performance of the systems for the foreseen application as viscosupplement was also verified. Cytocompatibility of developed systems toward fibroblasts and human chondrocytes was assessed. © 2020 Taylor & Francis Group, LLC.
Consumi, M., Leone, G., Pepi, S., Pardini, A., Lamponi, S., Bonechi, C., et al. (2022). Calcium ions hyaluronan/gellan gum protective shell for delivery of oleuropein in the knee. INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS, 71(6), 414-424 [10.1080/00914037.2020.1848831].
Calcium ions hyaluronan/gellan gum protective shell for delivery of oleuropein in the knee
Consumi M.;Leone G.
;Pepi S.;Pardini A.;Lamponi S.;Bonechi C.;Tamasi G.;Rossi C.;Magnani A.
2022-01-01
Abstract
Oleuropein has several beneficial properties. Strong evidences of its role in preventing osteoarthritis and playing analgesic and sedative effects are gaining. Starting from that, we entrapped a vegetal bioactive matrix rich in oleuropein into calcium ions crosslinked gellan gum and hyaluronan formulations. Infrared spectroscopy and thermal analysis confirmed the absence of significant interactions between the polysaccharide shells and the bioactive matrix, thus guaranteeing a burst release of oleuropein. The adequate mechanical performance of the systems for the foreseen application as viscosupplement was also verified. Cytocompatibility of developed systems toward fibroblasts and human chondrocytes was assessed. © 2020 Taylor & Francis Group, LLC.File | Dimensione | Formato | |
---|---|---|---|
82-IJPMPB(2022)-CaHYAL.pdf
non disponibili
Descrizione: Articolo
Tipologia:
PDF editoriale
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
3.94 MB
Formato
Adobe PDF
|
3.94 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/1140142