IRIS
BRINDISI, MARGHERITA
 Distribuzione geografica
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Continente #
NA - Nord America 6.468
EU - Europa 5.013
AS - Asia 2.091
SA - Sud America 339
AF - Africa 129
OC - Oceania 11
Continente sconosciuto - Info sul continente non disponibili 7
Totale 14.058
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Nazione #
US - Stati Uniti d'America 6.393
GB - Regno Unito 1.261
RU - Federazione Russa 983
IT - Italia 902
CN - Cina 730
SG - Singapore 603
IE - Irlanda 542
DE - Germania 282
UA - Ucraina 272
SE - Svezia 270
BR - Brasile 268
VN - Vietnam 225
FR - Francia 204
HK - Hong Kong 166
FI - Finlandia 120
IN - India 77
TR - Turchia 68
ZA - Sudafrica 64
CA - Canada 43
KR - Corea 39
NL - Olanda 34
BD - Bangladesh 32
AR - Argentina 29
ES - Italia 23
IQ - Iraq 22
CZ - Repubblica Ceca 21
JP - Giappone 20
MX - Messico 18
PL - Polonia 18
AT - Austria 17
GR - Grecia 16
CI - Costa d'Avorio 15
BE - Belgio 14
MA - Marocco 14
UZ - Uzbekistan 13
NG - Nigeria 11
PK - Pakistan 10
CO - Colombia 9
ID - Indonesia 9
IR - Iran 9
SA - Arabia Saudita 9
AU - Australia 8
EG - Egitto 8
JO - Giordania 7
AZ - Azerbaigian 6
CL - Cile 6
EC - Ecuador 6
IL - Israele 6
PE - Perù 6
PY - Paraguay 6
VE - Venezuela 6
JM - Giamaica 5
KZ - Kazakistan 5
TW - Taiwan 5
AE - Emirati Arabi Uniti 4
DK - Danimarca 4
ET - Etiopia 4
EU - Europa 4
GE - Georgia 4
KE - Kenya 4
NP - Nepal 4
OM - Oman 4
RO - Romania 4
TN - Tunisia 4
BG - Bulgaria 3
BO - Bolivia 3
BY - Bielorussia 3
LB - Libano 3
LT - Lituania 3
NO - Norvegia 3
PH - Filippine 3
SN - Senegal 3
XK - ???statistics.table.value.countryCode.XK??? 3
AL - Albania 2
CH - Svizzera 2
CR - Costa Rica 2
HN - Honduras 2
HU - Ungheria 2
KG - Kirghizistan 2
KH - Cambogia 2
LV - Lettonia 2
MD - Moldavia 2
NI - Nicaragua 2
TV - Tuvalu 2
AO - Angola 1
BB - Barbados 1
DO - Repubblica Dominicana 1
DZ - Algeria 1
HR - Croazia 1
LA - Repubblica Popolare Democratica del Laos 1
MT - Malta 1
NZ - Nuova Zelanda 1
PT - Portogallo 1
RS - Serbia 1
SY - Repubblica araba siriana 1
TJ - Tagikistan 1
TM - Turkmenistan 1
TT - Trinidad e Tobago 1
Totale 14.058
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Città #
Southend 1.131
Fairfield 795
Ashburn 649
Dallas 634
Dublin 538
Woodbridge 368
Siena 336
Seattle 326
Houston 302
Wilmington 288
Chandler 287
Singapore 285
Cambridge 284
Moscow 251
Jacksonville 228
San Jose 222
Santa Clara 219
Beijing 210
Milan 188
Ann Arbor 178
Hong Kong 157
Princeton 101
The Dalles 87
Dearborn 82
New York 80
Los Angeles 74
Nanjing 74
Rome 72
Helsinki 64
Ho Chi Minh City 60
Hanoi 59
Izmir 59
Council Bluffs 58
Johannesburg 58
Lauterbourg 53
San Diego 49
Munich 45
Boardman 43
Hefei 43
Shanghai 39
Fremont 38
San Mateo 38
Seoul 37
Buffalo 27
Orem 27
São Paulo 27
Nanchang 26
London 24
Columbus 22
Guangzhou 22
Bengaluru 21
Lappeenranta 20
Washington 20
Shenyang 19
Brno 18
Jinan 18
Montreal 17
Redwood City 17
San Francisco 17
Warsaw 17
Hebei 16
Lancaster 16
Berlin 15
Tokyo 15
Abidjan 14
Brussels 14
Da Nang 14
Düsseldorf 14
Kunming 14
Maastricht 14
Turin 14
Atlanta 13
Baghdad 13
Nuremberg 13
Stockholm 13
Florence 12
Frankfurt am Main 12
Haiphong 12
Málaga 12
Norwalk 12
Vienna 12
Abuja 11
Avellino 11
Brooklyn 11
Chicago 11
Denver 11
Phoenix 11
Redondo Beach 11
Tashkent 11
Tianjin 11
Menlo Park 10
Toronto 10
Venezia 10
Aachen 9
Boston 9
Changsha 9
Chennai 9
Naples 9
Poplar 9
Portsmouth 9
Totale 10.024
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Nome #
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 444
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 406
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome 396
Development of novel cyclic peptides as pro-apoptotic agents 390
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 389
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 370
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 365
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 345
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds 334
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 332
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 322
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 320
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 315
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 313
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 305
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 296
Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases 282
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds 279
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents 279
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 279
Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity 273
Telomerase-based cancer therapeutics: a review on their clinical trials 269
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 252
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation 252
Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders 240
Computational tool for fast in silico evaluation of hERG K+ channel affinity 236
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 232
Screening and phenotypical characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) inhibitors as multistage antischistosomal agents 232
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 231
Design, Synthesis, Biological Evaluation, and X‐ray Studies of HIV‐1 Protease Inhibitors with Modified P2′ Ligands of Darunavir 230
Achmatowicz reaction and its application in the syntheses of bioactive molecules 225
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 225
Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition 220
Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands 218
Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex 217
Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1 '-P2 ' ligands 217
Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants 217
Site-directed mutagenesis of key residues unveiled a novel allosteric site on human adenosine kinase for Pyrrolobenzoxa(thia)zepinone non-nucleoside inhibitors 205
Organic Carbamates in Drug Design and Medicinal Chemistry 200
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HCV-targeted Antivirals: Current Status and Future Challenges 194
Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis 194
Rational design of the first difluorostatone-based PfSUB1 inhibitors 191
Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effects on potency and selectivity 191
Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand 189
The Curtius rearrangement: mechanistic insight and recent applications in natural product syntheses 179
The Curtius Rearrangement: Applications in Modern Drug Discovery and Medicinal Chemistry 174
Highly stereoselective asymmetric aldol routes to tert-butyl-2-(3,5-difluorophenyl)-1-oxiran-2-yl)ethyl)carbamates: Building blocks for novel protease inhibitors 163
Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand 162
Development of a practical and scalable route for the preparation of the deacetoxytubuvaline (dTuv) fragment of pretubulysin and analogs 159
Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure–Activity Relationship Studies 154
Nature Inspired Molecular Design: Stereoselective Synthesis of Bicyclic and Polycyclic Ethers for Potent HIV-1 Protease Inhibitors 150
Exploring clotrimazole-based pharmacophore: 3D-QSAR studies and synthesis of novel antiplasmodial agents 131
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Plasmodium falciparum subtilisin-like protease 1: discovery of potent difluorostatone-based inhibitors 86
Sustainable Joullié–Ugi and Continuous Flow Implementation Led to Novel Captopril-Inspired Broad-Spectrum Metallo-β-Lactamase Inhibitors 84
Polypharmacology of dopamine receptor ligands 84
Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents 66
Harder than Metal: Challenging Antimicrobial Resistance with Metallo-β-lactamase Inhibitors 15
Totale 14.312
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Categoria #
all - tutte 39.391
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 39.391
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022903 70 105 71 39 36 21 47 24 37 165 111 177
2022/20231.003 57 89 147 134 108 200 22 87 100 25 23 11
2023/2024927 32 15 85 34 43 275 294 35 6 40 16 52
2024/20251.539 51 76 217 91 177 104 20 57 184 75 153 334
2025/20264.184 287 494 496 519 858 190 484 136 118 212 68 322
2026/202748 48 0 0 0 0 0 0 0 0 0 0 0
Totale 14.312