IRIS
BRINDISI, MARGHERITA
 Distribuzione geografica
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Continente #
NA - Nord America 4.493
EU - Europa 3.534
AS - Asia 557
AF - Africa 17
SA - Sud America 8
OC - Oceania 5
Continente sconosciuto - Info sul continente non disponibili 4
Totale 8.618
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Nazione #
US - Stati Uniti d'America 4.482
GB - Regno Unito 1.212
IT - Italia 548
IE - Irlanda 537
CN - Cina 392
UA - Ucraina 267
SE - Svezia 258
DE - Germania 204
RU - Federazione Russa 201
FR - Francia 130
FI - Finlandia 91
TR - Turchia 60
SG - Singapore 58
CZ - Repubblica Ceca 16
BE - Belgio 14
CI - Costa d'Avorio 14
GR - Grecia 14
ES - Italia 13
AT - Austria 12
CA - Canada 11
IR - Iran 8
VN - Vietnam 8
IN - India 6
JP - Giappone 6
AU - Australia 4
EU - Europa 4
IL - Israele 4
NL - Olanda 4
BG - Bulgaria 3
CL - Cile 3
EG - Egitto 3
AE - Emirati Arabi Uniti 2
HU - Ungheria 2
KR - Corea 2
KZ - Kazakistan 2
NO - Norvegia 2
PE - Perù 2
RO - Romania 2
AL - Albania 1
AZ - Azerbaigian 1
BD - Bangladesh 1
BO - Bolivia 1
BR - Brasile 1
CO - Colombia 1
DK - Danimarca 1
GE - Georgia 1
ID - Indonesia 1
KG - Kirghizistan 1
KH - Cambogia 1
LA - Repubblica Popolare Democratica del Laos 1
LV - Lettonia 1
NZ - Nuova Zelanda 1
RS - Serbia 1
TJ - Tagikistan 1
TM - Turkmenistan 1
Totale 8.618
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Città #
Southend 1.131
Fairfield 795
Dublin 534
Ashburn 495
Woodbridge 368
Siena 335
Seattle 318
Houston 296
Chandler 287
Wilmington 287
Cambridge 284
Jacksonville 228
Ann Arbor 178
Princeton 101
Beijing 100
Dearborn 82
Nanjing 71
Izmir 58
New York 51
San Diego 48
Helsinki 46
Boardman 43
Fremont 38
San Mateo 38
Singapore 33
Shanghai 28
Nanchang 26
Washington 20
Lappeenranta 19
Shenyang 18
Jinan 17
Redwood City 17
Brno 16
Hebei 16
Lancaster 16
Moscow 16
Abidjan 14
Brussels 14
London 14
Kunming 13
Milan 13
Málaga 12
Norwalk 12
Guangzhou 11
San Francisco 11
Vienna 11
Avellino 10
Düsseldorf 10
Florence 10
Menlo Park 10
Venezia 10
Aachen 9
Catanzaro 8
Dong Ket 8
Jiaxing 8
Los Angeles 8
Ningbo 8
Tianjin 8
Toronto 8
Changsha 7
Hefei 7
Munich 7
Borgo San Lorenzo 6
Palo Alto 5
Rome 5
Taizhou 5
Dallas 4
Frankfurt am Main 4
Hangzhou 4
Lanuvio 4
Zhengzhou 4
Certaldo 3
Edinburgh 3
Genova 3
North Branford 3
Nottingham 3
Nuremberg 3
Serra 3
Sofia 3
St Petersburg 3
Torino 3
Almaty 2
Andover 2
Cleveland 2
Empoli 2
Falls Church 2
Fort Worth 2
Groningen 2
Haikou 2
Hamburg 2
Hanover 2
Hounslow 2
Islington 2
Jinhua 2
Lanzhou 2
Leawood 2
Lima 2
Monselice 2
Nagold 2
New Bedfont 2
Totale 6.824
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Nome #
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 267
Development of novel cyclic peptides as pro-apoptotic agents 266
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 260
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 253
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 248
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome 245
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 227
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds 226
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 213
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 211
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 211
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 209
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 197
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 196
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 196
null 195
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 193
Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity 185
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 170
Telomerase-based cancer therapeutics: a review on their clinical trials 168
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 166
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 159
Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases 154
Design, Synthesis, Biological Evaluation, and X‐ray Studies of HIV‐1 Protease Inhibitors with Modified P2′ Ligands of Darunavir 151
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents 149
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 147
Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders 145
Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants 144
Achmatowicz reaction and its application in the syntheses of bioactive molecules 143
Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands 137
Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1 '-P2 ' ligands 136
Computational tool for fast in silico evaluation of hERG K+ channel affinity 132
Site-directed mutagenesis of key residues unveiled a novel allosteric site on human adenosine kinase for Pyrrolobenzoxa(thia)zepinone non-nucleoside inhibitors 131
Organic Carbamates in Drug Design and Medicinal Chemistry 130
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds 128
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 128
Rational design of the first difluorostatone-based PfSUB1 inhibitors 124
Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex 124
Screening and phenotypical characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) inhibitors as multistage antischistosomal agents 124
Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition 121
Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand 120
The Curtius rearrangement: mechanistic insight and recent applications in natural product syntheses 116
Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand 116
Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis 112
Highly stereoselective asymmetric aldol routes to tert-butyl-2-(3,5-difluorophenyl)-1-oxiran-2-yl)ethyl)carbamates: Building blocks for novel protease inhibitors 111
The Curtius Rearrangement: Applications in Modern Drug Discovery and Medicinal Chemistry 110
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation 110
HCV-targeted Antivirals: Current Status and Future Challenges 109
null 109
Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effects on potency and selectivity 104
null 101
null 99
Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure–Activity Relationship Studies 92
Nature Inspired Molecular Design: Stereoselective Synthesis of Bicyclic and Polycyclic Ethers for Potent HIV-1 Protease Inhibitors 91
null 90
Development of a practical and scalable route for the preparation of the deacetoxytubuvaline (dTuv) fragment of pretubulysin and analogs 55
Exploring clotrimazole-based pharmacophore: 3D-QSAR studies and synthesis of novel antiplasmodial agents 37
Polypharmacology of dopamine receptor ligands 29
Plasmodium falciparum subtilisin-like protease 1: discovery of potent difluorostatone-based inhibitors 27
Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents 16
Totale 8.863
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Categoria #
all - tutte 24.466
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 24.466
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.888 0 0 158 323 163 216 200 232 222 186 58 130
2020/20211.876 64 158 68 151 157 298 183 209 111 300 112 65
2021/2022903 70 105 71 39 36 21 47 24 37 165 111 177
2022/20231.003 57 89 147 134 108 200 22 87 100 25 23 11
2023/2024927 32 15 85 34 43 275 294 35 6 40 16 52
2024/2025322 51 76 195 0 0 0 0 0 0 0 0 0
Totale 8.863