IRIS
BRINDISI, MARGHERITA
 Distribuzione geografica
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Continente #
NA - Nord America 6.133
EU - Europa 4.661
AS - Asia 699
SA - Sud America 8
OC - Oceania 7
AF - Africa 5
Continente sconosciuto - Info sul continente non disponibili 5
Totale 11.518
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Nazione #
US - Stati Uniti d'America 6.111
GB - Regno Unito 1.643
IE - Irlanda 802
IT - Italia 693
CN - Cina 565
SE - Svezia 417
UA - Ucraina 381
DE - Germania 296
FR - Francia 201
FI - Finlandia 118
TR - Turchia 76
CA - Canada 22
ES - Italia 21
BE - Belgio 20
GR - Grecia 15
RU - Federazione Russa 15
VN - Vietnam 15
AT - Austria 12
IN - India 10
JP - Giappone 10
IR - Iran 7
AU - Australia 6
NL - Olanda 6
EU - Europa 5
ID - Indonesia 5
BR - Brasile 4
EG - Egitto 4
RO - Romania 4
BG - Bulgaria 3
IL - Israele 3
KR - Corea 3
PL - Polonia 3
RS - Serbia 3
SG - Singapore 3
CL - Cile 2
DK - Danimarca 2
HU - Ungheria 2
NO - Norvegia 2
AZ - Azerbaigian 1
CO - Colombia 1
KZ - Kazakistan 1
LV - Lettonia 1
NZ - Nuova Zelanda 1
PE - Perù 1
PT - Portogallo 1
ZA - Sudafrica 1
Totale 11.518
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Città #
Southend 1.521
Fairfield 1.081
Dublin 798
Ashburn 650
Woodbridge 493
Chandler 435
Seattle 429
Houston 419
Cambridge 385
Wilmington 384
Siena 371
Jacksonville 325
Ann Arbor 257
Beijing 146
Princeton 142
Nanjing 108
Dearborn 97
Izmir 70
New York 66
San Diego 59
Fremont 58
Helsinki 57
Boardman 56
San Mateo 48
Shanghai 43
Nanchang 38
Washington 33
Lancaster 27
Redwood City 23
Shenyang 23
Hebei 22
Venezia 21
Brussels 20
Málaga 20
Norwalk 20
Florence 19
Kunming 19
Jinan 18
Aachen 17
Lappeenranta 17
London 17
Jiaxing 16
Milan 16
Dong Ket 15
Ningbo 14
Düsseldorf 13
Guangzhou 13
Tianjin 13
Avellino 10
Hefei 10
Menlo Park 10
San Francisco 10
Vienna 10
Ottawa 9
Catanzaro 8
Los Angeles 8
Toronto 8
Borgo San Lorenzo 7
Changsha 7
Hangzhou 7
Rome 7
Taizhou 7
Hanover 6
Palo Alto 6
Andover 5
Maletto 5
Pisa 5
Serra 5
Tokyo 5
Zhengzhou 5
Chiswick 4
Edinburgh 4
Hounslow 4
Lanuvio 4
Leawood 4
New Bedfont 4
Palermo 4
Parma 4
Belgrade 3
Certaldo 3
Fontaneto d'Agogna 3
Genova 3
Groningen 3
Haikou 3
Mestre 3
North Branford 3
Nottingham 3
Philadelphia 3
Qingdao 3
Sofia 3
Torino 3
Winnipeg 3
Bari 2
Cairo 2
Campinas 2
Centrale 2
Cleveland 2
Empoli 2
Falls Church 2
Fort Worth 2
Totale 9.202
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Nome #
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 262
Development of novel cyclic peptides as pro-apoptotic agents 252
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 246
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 241
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome 236
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 235
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 218
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds 211
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 207
Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases 206
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 203
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 201
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 199
null 195
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 192
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 192
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 187
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 185
Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity 180
Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization 179
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior 174
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues 171
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 167
Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases 163
Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues 158
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 157
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors 156
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides 155
Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials 155
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 154
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 154
Design, Synthesis, Biological Evaluation, and X‐ray Studies of HIV‐1 Protease Inhibitors with Modified P2′ Ligands of Darunavir 149
Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation 148
Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases 146
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 141
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 140
Achmatowicz reaction and its application in the syntheses of bioactive molecules 139
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils 138
Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation 138
Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders 137
Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants 137
Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands 132
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties 131
Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1 '-P2 ' ligands 130
Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors 129
Organic Carbamates in Drug Design and Medicinal Chemistry 128
null 123
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 122
Rational design of the first difluorostatone-based PfSUB1 inhibitors 120
null 120
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds 118
Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex 118
Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand 117
null 115
Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand 114
Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents 114
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants 113
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the ‘‘primer grip’’ region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants. 113
null 113
The Curtius rearrangement: mechanistic insight and recent applications in natural product syntheses 111
null 111
null 109
Highly stereoselective asymmetric aldol routes to tert-butyl-2-(3,5-difluorophenyl)-1-oxiran-2-yl)ethyl)carbamates: Building blocks for novel protease inhibitors 109
The Curtius Rearrangement: Applications in Modern Drug Discovery and Medicinal Chemistry 108
Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis 106
null 105
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation 104
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas 102
null 101
HCV-targeted Antivirals: Current Status and Future Challenges 100
The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells. 100
null 99
Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effects on potency and selectivity 97
Novel, Potent and Selective Quinoxaline-Based 5-HT3 Receptor Ligands. 1. Further Structure-activity Relationships and Pharmacological Characterization. 93
Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure–Activity Relationship Studies 90
null 90
Nature Inspired Molecular Design: Stereoselective Synthesis of Bicyclic and Polycyclic Ethers for Potent HIV-1 Protease Inhibitors 88
The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors. 78
Computational tool for fast in silico evaluation of hERG K+ channel affinity 44
Development of a practical and scalable route for the preparation of the deacetoxytubuvaline (dTuv) fragment of pretubulysin and analogs 41
Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: Definition of the structural determinants for enzyme inhibition 39
In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors 33
Exploring clotrimazole-based pharmacophore: 3D-QSAR studies and synthesis of novel antiplasmodial agents 30
Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies 30
Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors 30
Polypharmacology of dopamine receptor ligands 25
Plasmodium falciparum subtilisin-like protease 1: discovery of potent difluorostatone-based inhibitors 22
Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach 22
Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents 14
Totale 11.805
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Categoria #
all - tutte 32.196
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 32.196
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019796 0 0 0 0 0 0 0 0 0 0 414 382
2019/20202.936 298 91 214 456 215 293 269 324 279 249 85 163
2020/20212.461 92 204 92 209 193 393 220 285 159 339 166 109
2021/20221.331 113 164 112 80 51 30 80 46 51 203 148 253
2022/20231.528 90 135 225 212 158 305 34 121 156 35 38 19
2023/20241.282 62 22 128 64 78 385 444 42 6 47 4 0
Totale 11.805