IRIS
BRINDISI, MARGHERITA
 Distribuzione geografica
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Continente #
NA - Nord America 4.710
EU - Europa 3.606
AS - Asia 663
AF - Africa 18
SA - Sud America 9
OC - Oceania 5
Continente sconosciuto - Info sul continente non disponibili 4
Totale 9.015
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Nazione #
US - Stati Uniti d'America 4.698
GB - Regno Unito 1.212
IT - Italia 559
IE - Irlanda 537
CN - Cina 439
UA - Ucraina 267
SE - Svezia 258
RU - Federazione Russa 248
DE - Germania 207
FR - Francia 130
SG - Singapore 108
FI - Finlandia 96
TR - Turchia 60
CZ - Repubblica Ceca 17
GR - Grecia 15
BE - Belgio 14
CI - Costa d'Avorio 14
ES - Italia 13
AT - Austria 12
CA - Canada 12
IR - Iran 9
VN - Vietnam 8
IN - India 6
JP - Giappone 6
NL - Olanda 6
AU - Australia 4
EG - Egitto 4
EU - Europa 4
IL - Israele 4
AZ - Azerbaigian 3
BG - Bulgaria 3
CL - Cile 3
AE - Emirati Arabi Uniti 2
BD - Bangladesh 2
DK - Danimarca 2
GE - Georgia 2
HU - Ungheria 2
ID - Indonesia 2
KR - Corea 2
KZ - Kazakistan 2
NO - Norvegia 2
PE - Perù 2
RO - Romania 2
UZ - Uzbekistan 2
AL - Albania 1
AR - Argentina 1
BO - Bolivia 1
BR - Brasile 1
BY - Bielorussia 1
CO - Colombia 1
JO - Giordania 1
KG - Kirghizistan 1
KH - Cambogia 1
LA - Repubblica Popolare Democratica del Laos 1
LV - Lettonia 1
NZ - Nuova Zelanda 1
RS - Serbia 1
TJ - Tagikistan 1
TM - Turkmenistan 1
Totale 9.015
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Città #
Southend 1.131
Fairfield 795
Dublin 534
Ashburn 495
Woodbridge 368
Siena 336
Seattle 318
Houston 296
Chandler 287
Wilmington 287
Cambridge 284
Jacksonville 228
Santa Clara 197
Ann Arbor 178
Beijing 102
Princeton 101
Dearborn 82
Singapore 82
Nanjing 72
Izmir 58
New York 51
Helsinki 50
San Diego 48
Boardman 43
Fremont 38
San Mateo 38
Shanghai 32
Nanchang 26
Washington 20
Lappeenranta 19
Shenyang 19
Jinan 17
Redwood City 17
Brno 16
Hebei 16
Lancaster 16
Moscow 16
Abidjan 14
Brussels 14
Guangzhou 14
Kunming 14
London 14
Milan 13
San Francisco 13
Málaga 12
Norwalk 12
Vienna 11
Avellino 10
Düsseldorf 10
Florence 10
Los Angeles 10
Menlo Park 10
Tianjin 10
Venezia 10
Aachen 9
Munich 9
Catanzaro 8
Changsha 8
Dong Ket 8
Jiaxing 8
Ningbo 8
Toronto 8
Hefei 7
Borgo San Lorenzo 6
Palo Alto 5
Rome 5
Taizhou 5
Zhengzhou 5
Dallas 4
Frankfurt am Main 4
Hangzhou 4
Lanuvio 4
Nuremberg 4
Certaldo 3
Edinburgh 3
Genova 3
Haikou 3
Harbin 3
North Branford 3
Nottingham 3
Serra 3
Sofia 3
St Petersburg 3
Torino 3
Almaty 2
Andover 2
Athens 2
Baku 2
Baoding 2
Cairo 2
Cleveland 2
Dhaka 2
Empoli 2
Falls Church 2
Fort Worth 2
Groningen 2
Hamburg 2
Hanover 2
Hounslow 2
Islington 2
Totale 7.098
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Nome #
Development of novel cyclic peptides as pro-apoptotic agents 278
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 276
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 268
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 262
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 254
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome 254
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 236
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds 232
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 221
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 220
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 218
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 218
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 207
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 204
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 202
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 202
null 195
Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity 194
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 178
Telomerase-based cancer therapeutics: a review on their clinical trials 178
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 174
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 166
Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases 161
Design, Synthesis, Biological Evaluation, and X‐ray Studies of HIV‐1 Protease Inhibitors with Modified P2′ Ligands of Darunavir 157
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents 155
Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders 154
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 154
Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants 153
Achmatowicz reaction and its application in the syntheses of bioactive molecules 148
Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands 143
Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1 '-P2 ' ligands 141
Computational tool for fast in silico evaluation of hERG K+ channel affinity 140
Site-directed mutagenesis of key residues unveiled a novel allosteric site on human adenosine kinase for Pyrrolobenzoxa(thia)zepinone non-nucleoside inhibitors 138
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 135
Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex 134
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds 133
Organic Carbamates in Drug Design and Medicinal Chemistry 133
Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition 133
Screening and phenotypical characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) inhibitors as multistage antischistosomal agents 133
Rational design of the first difluorostatone-based PfSUB1 inhibitors 130
Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand 125
The Curtius rearrangement: mechanistic insight and recent applications in natural product syntheses 123
Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand 120
Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis 120
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation 119
The Curtius Rearrangement: Applications in Modern Drug Discovery and Medicinal Chemistry 117
HCV-targeted Antivirals: Current Status and Future Challenges 116
Highly stereoselective asymmetric aldol routes to tert-butyl-2-(3,5-difluorophenyl)-1-oxiran-2-yl)ethyl)carbamates: Building blocks for novel protease inhibitors 115
Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effects on potency and selectivity 112
null 109
null 101
null 99
Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure–Activity Relationship Studies 96
Nature Inspired Molecular Design: Stereoselective Synthesis of Bicyclic and Polycyclic Ethers for Potent HIV-1 Protease Inhibitors 95
null 90
Development of a practical and scalable route for the preparation of the deacetoxytubuvaline (dTuv) fragment of pretubulysin and analogs 63
Exploring clotrimazole-based pharmacophore: 3D-QSAR studies and synthesis of novel antiplasmodial agents 43
Polypharmacology of dopamine receptor ligands 33
Plasmodium falciparum subtilisin-like protease 1: discovery of potent difluorostatone-based inhibitors 32
Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents 20
Totale 9.260
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Categoria #
all - tutte 26.663
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 26.663
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.028 0 0 0 0 0 0 200 232 222 186 58 130
2020/20211.876 64 158 68 151 157 298 183 209 111 300 112 65
2021/2022903 70 105 71 39 36 21 47 24 37 165 111 177
2022/20231.003 57 89 147 134 108 200 22 87 100 25 23 11
2023/2024927 32 15 85 34 43 275 294 35 6 40 16 52
2024/2025719 51 76 217 91 177 104 3 0 0 0 0 0
Totale 9.260