Design, synthesis and biological evaluation of simplified linear and cyclic peptidomimetic analogues of FR235222 (1), natural immunosuppressant and HDAC inhibitor, bearing hydroxyketone moiety as more stable zinc binding group, have been reported. Linear dipeptides (6a-b) show significant antiproliferative activities and are chosen to be promising lead compounds for further optimization, in order to elucidate molecule-enzyme surface recognition.
Rodriquez, M., Cini, E., Petricci, E., Anna Maria, D., Carmela, S., Randino, R. (2014). TRYPTOPHAN-BASED LINEAR DIPEPTIDESAND 1,4-DIKETOPIPERAZINES AS SIMPLIFIED SCAFFOLD OF THE NATURAL CYCLOTETRAPEPTIDE FR235222. PHARMACOLOGYONLINE, 3, 209-215.
TRYPTOPHAN-BASED LINEAR DIPEPTIDESAND 1,4-DIKETOPIPERAZINES AS SIMPLIFIED SCAFFOLD OF THE NATURAL CYCLOTETRAPEPTIDE FR235222
RODRIQUEZ, MANUELA;CINI, ELENA;PETRICCI, ELENA;RANDINO, ROSARIO
2014-01-01
Abstract
Design, synthesis and biological evaluation of simplified linear and cyclic peptidomimetic analogues of FR235222 (1), natural immunosuppressant and HDAC inhibitor, bearing hydroxyketone moiety as more stable zinc binding group, have been reported. Linear dipeptides (6a-b) show significant antiproliferative activities and are chosen to be promising lead compounds for further optimization, in order to elucidate molecule-enzyme surface recognition.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/999259
Attenzione
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo