Due to the large production and growing use of titanium dioxide nanoparticles (n-TiO2), their releasein the marine environment and their potential interaction with existing toxic contaminants represent agrowing concern for biota. Different end-points of genotoxicity were investigated in the European sea bassDicentrarchus labrax exposed to n-TiO2(1 mg L−1) either alone and combined with CdCl2(0.1 mg L−1) for7 days. DNA primary damage (comet assay), apoptotic cells (diffusion assay), occurrence of micronucleiand nuclear abnormalities (cytome assay) were assessed in peripheral erythrocytes and genomic stability(random amplified polymorphism DNA-PCR, RAPD assay) in muscle tissue. Results showed that genometemplate stability was reduced after CdCl2and n-TiO2exposure. Exposure to n-TiO2alone was responsiblefor chromosomal alteration but ineffective in terms of DNA damage; while the opposite was observedin CdCl2exposed specimens. Co-exposure apparently prevents the chromosomal damage and leads to apartial recovery of the genome template stability.
Scheda prodotto non validato
Scheda prodotto in fase di analisi da parte dello staff di validazione
|Titolo:||n-TiO2 and CdCl2 co-exposure to titanium dioxide nanoparticles and cadmium: Genomic, DNA and chromosomal damage evaluation in the marine fish European sea bass (Dicentrarchus labrax)|
|Citazione:||Nigro, M., Bernardeschi, M., Costagliola, D., DELLA TORRE, C., Frenzilli, G., Guidi, P., et al. (2015). n-TiO2 and CdCl2 co-exposure to titanium dioxide nanoparticles and cadmium: Genomic, DNA and chromosomal damage evaluation in the marine fish European sea bass (Dicentrarchus labrax). AQUATIC TOXICOLOGY, 168, 72-77.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
File in questo prodotto: