tWe investigated the influence of titanium dioxide nanoparticles (nano-TiO2) on the response to cad-mium in the gills of the marine mussel Mytilus galloprovincialis in terms of accumulation and toxicity.Mussels were in vivo exposed to nano-TiO2, CdCl2, alone and in combination. Several cellular biomarkerswere investigated in gills: ABC transport proteins and metallothioneins at gene/protein (abcb1, abcc-likeand mt-20) and functional level, GST activity, NO production and DNA damage (Comet assay). Accu-mulation of total Cd and titanium in gills as in whole soft tissue was also investigated. Significantresponses to Cd exposure were observed in mussel gills as up-regulation of abcb1 and mt-20 gene tran-scription, increases in total MT content, P-gp efflux and GST activity, DNA damage and NO production.Nano-TiO2alone increased P-gp efflux activity and NO production. When combined with Cd, nano-TiO2 reduced the metal-induced effects by significantly lowering abcb1 gene transcription, GST activity, andDNA damage, whereas, additive effects were observed on NO production. A lower concentration of Cdwas observed in the gills upon co-exposure, whereas, Ti levels were unaffected. A competitive effect inuptake/accumulation of nano-TiO2and Cd seems to occur in gills. A confirmation is given by the observedabsence of adsorption of Cd onto nano-TiO2in sea water media.
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|Titolo:||Titanium dioxide nanoparticles modulate the toxicological response to cadmium in the gills of Mytilus galloprovincialis|
|Citazione:||DELLA TORRE, C., Balbi, T., Grassi, G., Frenzilli, G., Bernardeschi, M., Smerilli, A., et al. (2015). Titanium dioxide nanoparticles modulate the toxicological response to cadmium in the gills of Mytilus galloprovincialis. JOURNAL OF HAZARDOUS MATERIALS, 297, 92-100.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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