Rat sarcoma virus (RAS)-induced tumorigenesis has been suggested to follow a three-stage model consisting of an initial RAS activation, senescence induction, and evasion of p53-dependent senescence checkpoints. While reactive oxygen species act as second messengers in RAS-induced senescence, they are also involved in oncogenic transformation by inducing proliferation and promoting mutations. In the current work, we investigated the role of extracellular superoxide dismutase (SOD3) in RAS-induced senescence and immortalization in vitro and in vivo. We used a mouse embryonic fibroblast (MEF) primary cell model along with immortalized and transformed human cell lines derived from papillary and anaplastic thyroid cancer.

Castellone, M.D., Langella, A., Cantara, S., Laurila, J.P., Laatikainen, L.E., Bellelli, R., et al. (2014). Extracellular superoxide dismutase induces mouse embryonic fibroblast proliferative burst, growth arrest, immortalization, and consequent in vivo tumorigenesis. ANTIOXIDANTS & REDOX SIGNALING, 21(10), 1460-74-1474 [10.1089/ars.2013.5475].

Extracellular superoxide dismutase induces mouse embryonic fibroblast proliferative burst, growth arrest, immortalization, and consequent in vivo tumorigenesis

CANTARA, SILVIA;PACINI, FURIO;
2014-01-01

Abstract

Rat sarcoma virus (RAS)-induced tumorigenesis has been suggested to follow a three-stage model consisting of an initial RAS activation, senescence induction, and evasion of p53-dependent senescence checkpoints. While reactive oxygen species act as second messengers in RAS-induced senescence, they are also involved in oncogenic transformation by inducing proliferation and promoting mutations. In the current work, we investigated the role of extracellular superoxide dismutase (SOD3) in RAS-induced senescence and immortalization in vitro and in vivo. We used a mouse embryonic fibroblast (MEF) primary cell model along with immortalized and transformed human cell lines derived from papillary and anaplastic thyroid cancer.
Castellone, M.D., Langella, A., Cantara, S., Laurila, J.P., Laatikainen, L.E., Bellelli, R., et al. (2014). Extracellular superoxide dismutase induces mouse embryonic fibroblast proliferative burst, growth arrest, immortalization, and consequent in vivo tumorigenesis. ANTIOXIDANTS & REDOX SIGNALING, 21(10), 1460-74-1474 [10.1089/ars.2013.5475].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/973275