An efficient synthesis of 3-substituted crotonaldehydes via alkyne-enol ether cross-metathesis in the presence of CuSO4 and in aqueous medium was developed. Crotonaldehydes were obtained in good yields from terminal aryl-alkynes as well as from terminal alkyl-alkynes. All of the reactions were carried out under microwave irradiation and were completed in a few minutes. Water was used as the cosolvent, making this approach safer, economic, and desiderable from an enviromental point of view.
Scheda prodotto non validato
Scheda prodotto in fase di analisi da parte dello staff di validazione
|Titolo:||Alkyne-enol ether cross-metathesis in the presence of CuSO. Direct formation of 3-substituted crotonaldehydes in aqueous medium|
|Rivista:||JOURNAL OF ORGANIC CHEMISTRY|
|Citazione:||Castagnolo, D., Botta, L., & Botta, M. (2009). Alkyne-enol ether cross-metathesis in the presence of CuSO. Direct formation of 3-substituted crotonaldehydes in aqueous medium. JOURNAL OF ORGANIC CHEMISTRY, 74, 3172-3174.|
|Appare nelle tipologie:||1.1 Articolo in rivista|