A fast and efficient protocol for the generation of substituted 5-arylidene rhodanines in a sequential one-pot two-step process combining the “Holmberg method” and the Knoevenagel condensation under microwave-assisted conditions has been developed. The final compounds 11a−k have been obtained in high yield and purity after a simple precipitation from methanol, making this procedure facile, practical, and rapid to execute.
Radi, M., Botta, L., Casaluce, G., Bernardini, M., Botta, M. (2010). A Practical One-Pot Two-Step Protocol for the Microwave-Assisted Synthesis of Highly Functionalized Rhodanine Derivatives. JOURNAL OF COMBINATORIAL CHEMISTRY, 12(1), 200-205 [10.1021/cc9001789].
A Practical One-Pot Two-Step Protocol for the Microwave-Assisted Synthesis of Highly Functionalized Rhodanine Derivatives
Radi, Marco;Botta, Lorenzo;Casaluce, Gianni;Bernardini, Martina;Botta, Maurizio
2010-01-01
Abstract
A fast and efficient protocol for the generation of substituted 5-arylidene rhodanines in a sequential one-pot two-step process combining the “Holmberg method” and the Knoevenagel condensation under microwave-assisted conditions has been developed. The final compounds 11a−k have been obtained in high yield and purity after a simple precipitation from methanol, making this procedure facile, practical, and rapid to execute.
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https://hdl.handle.net/11365/9453
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