A one-pot, two-step protocol for the microwave-assisted solid-phase synthesis of substituted benzoxazoles has been developed starting from different polymer-bound esters we previously designed as solid-supported reagents (SSRs) for the acylation of amines, alcohols and phenols. The combination of a parallel synthesizer and a microwave reactor allowed to quickly prepare a collection of substituted benzoxaxoles in high purity and satisfactory yields. This protocol is amenable for automation and could be used for the preparation of combinatorial libraries in drug discovery programs.

Radi, M., S., S., & Botta, M. (2008). A one-pot, two step microwave-assisted synthesis of highly functionalized benzoxazoles using solid-supported reagents (SSRs). TETRAHEDRON LETTERS, 49, 4464-4466 [10.1016/j.tetlet.2008.05.059].

A one-pot, two step microwave-assisted synthesis of highly functionalized benzoxazoles using solid-supported reagents (SSRs)

RADI, MARCO;BOTTA, MAURIZIO
2008

Abstract

A one-pot, two-step protocol for the microwave-assisted solid-phase synthesis of substituted benzoxazoles has been developed starting from different polymer-bound esters we previously designed as solid-supported reagents (SSRs) for the acylation of amines, alcohols and phenols. The combination of a parallel synthesizer and a microwave reactor allowed to quickly prepare a collection of substituted benzoxaxoles in high purity and satisfactory yields. This protocol is amenable for automation and could be used for the preparation of combinatorial libraries in drug discovery programs.
Radi, M., S., S., & Botta, M. (2008). A one-pot, two step microwave-assisted synthesis of highly functionalized benzoxazoles using solid-supported reagents (SSRs). TETRAHEDRON LETTERS, 49, 4464-4466 [10.1016/j.tetlet.2008.05.059].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/9451
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