Inhibiting COX: A small library of pyrazolopyriminines endowed with antiproliferative action was submitted to virtual screening against two COX isoforms. Three compounds were identified in silico as potentially selective COX-2 inhibitors. The biological assay confirmed one of them to be a COX-2 inhibitor with potency and selectivity comparable to known drugs.

S., A., A., A., Botta, M., A. T., Z., F., O., F., O., et al. (2010). Hit identification and biological evaluation of anticancer Pyrazolopyrimidines endowed with anti-inflammatory activity. CHEMMEDCHEM, 5, 1242-1246 [10.1002/cmdc.201000165].

Hit identification and biological evaluation of anticancer Pyrazolopyrimidines endowed with anti-inflammatory activity

BOTTA, MAURIZIO;
2010

Abstract

Inhibiting COX: A small library of pyrazolopyriminines endowed with antiproliferative action was submitted to virtual screening against two COX isoforms. Three compounds were identified in silico as potentially selective COX-2 inhibitors. The biological assay confirmed one of them to be a COX-2 inhibitor with potency and selectivity comparable to known drugs.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/9357
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