A practical microwave-assisted protocol for the synthesis of 2,6-disubstituted pyrimidinones has been developed. This approach is based on a domino Michael addition-cyclocondensation reaction between substituted thioureas/guanidines and acetylenecarboxylates. The application of such protocol for the synthesis of not easily accessible N-DABO derivatives as potential antiviral agents is also reported.
Botta, M., Casaluce, G., Botta, M. (2011). A domino Microwave-assisted protocol for the Synthesis of 2,6 Disubstituted Pyrimidinones. SYNLETT(14), 1997-2000 [10.1055/s-0030-1261174].
A domino Microwave-assisted protocol for the Synthesis of 2,6 Disubstituted Pyrimidinones
Botta, Maurizio;Casaluce, Gianni;
2011-01-01
Abstract
A practical microwave-assisted protocol for the synthesis of 2,6-disubstituted pyrimidinones has been developed. This approach is based on a domino Michael addition-cyclocondensation reaction between substituted thioureas/guanidines and acetylenecarboxylates. The application of such protocol for the synthesis of not easily accessible N-DABO derivatives as potential antiviral agents is also reported.
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https://hdl.handle.net/11365/9342
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