Chiral 1-phenyl-2-propynylamines are important building blocks for the synthesis of antifungal and antiaromatase agents related to bifonazole. In this report, a microwave-assisted Cu(I)-catalyzed 'click chemistry' approach has been employed to easily generate a small library of enantiomerically pure α-[4-(1-substituted)-1,2,3-triazol-4-yl]benzylacetamides starting from racemic propargylamines. These compounds could represent easily accessible intermediates for the synthesis of new antimicrobial agents. © 2007 Elsevier Ltd. All rights reserved.
Castagnolo, D., Dess, F., Radi, M., Botta, M. (2007). Synthesis of enantiomerically pure alpha-[4-(1-substituited)-1,2,3-triazol-4-yl]-benzylacetamides via microwave-assisted click chemistry: towards new potential antimicrobial agents. TETRAHEDRON-ASYMMETRY, 18(11), 1345-1350 [10.1016/j.tetasy.2007.06.007].
Synthesis of enantiomerically pure alpha-[4-(1-substituited)-1,2,3-triazol-4-yl]-benzylacetamides via microwave-assisted click chemistry: towards new potential antimicrobial agents
Botta, Maurizio
2007-01-01
Abstract
Chiral 1-phenyl-2-propynylamines are important building blocks for the synthesis of antifungal and antiaromatase agents related to bifonazole. In this report, a microwave-assisted Cu(I)-catalyzed 'click chemistry' approach has been employed to easily generate a small library of enantiomerically pure α-[4-(1-substituted)-1,2,3-triazol-4-yl]benzylacetamides starting from racemic propargylamines. These compounds could represent easily accessible intermediates for the synthesis of new antimicrobial agents. © 2007 Elsevier Ltd. All rights reserved.
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https://hdl.handle.net/11365/9223
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