Objectives: The clinical relevance of protein S deficiency in pregnant women remains controversial. Major debate exists regarding which parameter (total protein S antigen, free protein S antigen or functional protein S) should be evaluated in order to define protein S deficiency. The present study aimed to identify which of these parameters correlate with intrauterine growth restriction (IUGR). Study design: A retrospective case-control study of women with IUGR (n = 27) and healthy controls (n = 123) in the third trimester of pregnancy. Results: The maternal serum of women in the IUGR group had significantly lower levels of functional and free protein S compared with the control group: 54.07 ± 24.72% vs 65.20 ± 17.95% (p < 0.005) and 42.88 ± 11.01% vs 56.64 ± 13.30% (p < 0.0001), respectively. No significant correlation was found between total protein S and IUGR. Conclusions: Levels of functional and free protein S are correlated with IUGR. © 2011 Elsevier Ireland Ltd.
De Bonis, M., Sabatini, L., Galeazzi, L.R., Torricelli, M., Calzoni, P., Fineschi, D., et al. (2012). Maternal serum protein S forms in pregnancies complicated by intrauterine growth restriction. EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE BIOLOGY, 160(2), 142-146 [10.1016/j.ejogrb.2011.10.008].
Maternal serum protein S forms in pregnancies complicated by intrauterine growth restriction
De Bonis, Maria;Galeazzi, Luna R.;Torricelli, Michela;Calzoni, Paola;Novembri, Romina;Severi, Filiberto M.;Petraglia, Felice
2012-01-01
Abstract
Objectives: The clinical relevance of protein S deficiency in pregnant women remains controversial. Major debate exists regarding which parameter (total protein S antigen, free protein S antigen or functional protein S) should be evaluated in order to define protein S deficiency. The present study aimed to identify which of these parameters correlate with intrauterine growth restriction (IUGR). Study design: A retrospective case-control study of women with IUGR (n = 27) and healthy controls (n = 123) in the third trimester of pregnancy. Results: The maternal serum of women in the IUGR group had significantly lower levels of functional and free protein S compared with the control group: 54.07 ± 24.72% vs 65.20 ± 17.95% (p < 0.005) and 42.88 ± 11.01% vs 56.64 ± 13.30% (p < 0.0001), respectively. No significant correlation was found between total protein S and IUGR. Conclusions: Levels of functional and free protein S are correlated with IUGR. © 2011 Elsevier Ireland Ltd.
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https://hdl.handle.net/11365/8553
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