The synthesis of 7-chloro-2,3-dihydro-2-(2-methoxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine (2) is described. While the metaclazepam-like compound 2 showed an affinity for benzodiazepine receptor central type (CBZRs) comparable to that of metaclazepam (1a), its intermediates bearing the exocyclic double bond resulted more active.
Anzini, M., Cappelli, A., Vomero, S., Cagnotto, A., Skorupska, M. (1993). Synthesis and Receptor Binding Studies of 2-Functionalized 1,4-Benzodiazepine Derivatives as Potential Metaclazepam-like Antianxiety Agents. IL FARMACO, 48(7), 897-905.
Synthesis and Receptor Binding Studies of 2-Functionalized 1,4-Benzodiazepine Derivatives as Potential Metaclazepam-like Antianxiety Agents
Anzini, Maurizio;Cappelli, Andrea;Vomero, Salvatore;
1993-01-01
Abstract
The synthesis of 7-chloro-2,3-dihydro-2-(2-methoxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine (2) is described. While the metaclazepam-like compound 2 showed an affinity for benzodiazepine receptor central type (CBZRs) comparable to that of metaclazepam (1a), its intermediates bearing the exocyclic double bond resulted more active.
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https://hdl.handle.net/11365/8026
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