A number of pyruvic acid and methylpyruvate alpha-(N)-heterocyclic hydrazones has been synthesized. Bis-heterocyclic hydrazones were obtained from reaction with pyruvic carboxaldehyde. Some complexes of Ni(II) were prepared and characterized as neutral complexes. All these compounds have been evaluated for cytotoxicity against P388 and HL-60 leukemia.

Savini, L., Massarelli, P., Chiasserini, L., Nencini, C., & Pellerano, C. (1997). Chelating agents as potential antitumorals: alfa-(N)-heterocyclic hydrazones and bis-alfa-(N)-heterocyclic hydrazones. IL FARMACO, 52(10), 609-613.

Chelating agents as potential antitumorals: alfa-(N)-heterocyclic hydrazones and bis-alfa-(N)-heterocyclic hydrazones

SAVINI, LUISA;MASSARELLI, PAOLA;CHIASSERINI, LUISA;NENCINI, CRISTINA;PELLERANO, CESARE
1997

Abstract

A number of pyruvic acid and methylpyruvate alpha-(N)-heterocyclic hydrazones has been synthesized. Bis-heterocyclic hydrazones were obtained from reaction with pyruvic carboxaldehyde. Some complexes of Ni(II) were prepared and characterized as neutral complexes. All these compounds have been evaluated for cytotoxicity against P388 and HL-60 leukemia.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/7919
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