The structure of the copper complex of melanostatin was investigated by NMR relaxation rate analysis and ESR spectral simulation. A 1:1 complex is formed at any ligand:metal ratio. The assumption that the motional correlation time equals that for the peptide free in solution allowed us to calculate several copper-carbon and copper-proton distances that were used to build up a molecular model of the metal complex. The metal ion is in a distorted tetrahedral arrangement and is coordinated by four nitrogen atoms. (C) 1998 Elsevier Science S.A. All rights reserved.
Basosi, R., Gaggelli, E., Gaggelli, N., Pogni, R., Valensin, G. (1998). ESR and NMR investigation of Structure and Dynamics of the Cu(II) Complex of Melanostatin in DMSO Solution. INORGANICA CHIMICA ACTA, 276(1-2), 274-278 [10.1016/s0020-1693(97)06141-0].
ESR and NMR investigation of Structure and Dynamics of the Cu(II) Complex of Melanostatin in DMSO Solution
Basosi, Riccardo;Gaggelli, Elena;Gaggelli, Nicola;Pogni, Rebecca;Valensin, Gianni
1998-01-01
Abstract
The structure of the copper complex of melanostatin was investigated by NMR relaxation rate analysis and ESR spectral simulation. A 1:1 complex is formed at any ligand:metal ratio. The assumption that the motional correlation time equals that for the peptide free in solution allowed us to calculate several copper-carbon and copper-proton distances that were used to build up a molecular model of the metal complex. The metal ion is in a distorted tetrahedral arrangement and is coordinated by four nitrogen atoms. (C) 1998 Elsevier Science S.A. All rights reserved.
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https://hdl.handle.net/11365/7123
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