A new compound, carbamoyl-pyridoxal 5'-phosphate (C-PLP), was synthetized by condensation of pyridoxal 5'-phosphate (PLP) with KCNO. It may be obtained under certain physiological conditions of pH, temperature and concentration of reagents. Formation and degradation of C-PLP are readily reversible chemical reactions, not involving enzymes, at least in rat tissues. However, different considerations suggest that synthesis and breakdown of C-PLP play a biological role in the cell, providing 'protective synthesis' and a 'variable reservoir' of PLP and KCNO, which can be trapped by other proteins, apoenzymes and metabolites, to regulate many cell metabolic functions.
Terzuoli, L., Pizzichini, M., Pagani, R., Guerranti, R., Ponticelli, F., Leoncini, R., et al. (1997). Biological Role of Carbamoyl pyridoxal 5'-phosphate. CELLULAR AND MOLECULAR LIFE SCIENCES, 320(6), 435-440 [10.1016/S0764-4469(97)81970-1].
Biological Role of Carbamoyl pyridoxal 5'-phosphate
Ponticelli, Fabio;Leoncini, Roberto;
1997-01-01
Abstract
A new compound, carbamoyl-pyridoxal 5'-phosphate (C-PLP), was synthetized by condensation of pyridoxal 5'-phosphate (PLP) with KCNO. It may be obtained under certain physiological conditions of pH, temperature and concentration of reagents. Formation and degradation of C-PLP are readily reversible chemical reactions, not involving enzymes, at least in rat tissues. However, different considerations suggest that synthesis and breakdown of C-PLP play a biological role in the cell, providing 'protective synthesis' and a 'variable reservoir' of PLP and KCNO, which can be trapped by other proteins, apoenzymes and metabolites, to regulate many cell metabolic functions.
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https://hdl.handle.net/11365/6833
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