Different approaches to the title ring systems were examined, based on the cleavage of the N–O bond in the isoxazolopyridine-4-thiols (3) and (4) which afforded the hydroxy derivatives (6) and (7), respectively, in moderate to good yields. 3-Methylisothiazolo-[5,4-b]- and -[4,5-c]-pyridine (11) and (18), as well as several functionalized derivatives, were easily obtained from these key intermediates through the corresponding 4,6-dichloroisothiazolopyridines (10) and (17).
Chimichi, S., Nesi, R., Ponticelli, F., Tedeschi, P. (1990). Synthetic Investigation on Isothiazolo[5,4-b]- and [4,5-c]pyridines. JOURNAL OF THE CHEMICAL SOCIETY. PERKIN TRANSACTIONS. I(5), 1477-1480 [10.1039/p19900001477].
Synthetic Investigation on Isothiazolo[5,4-b]- and [4,5-c]pyridines
PONTICELLI, F.;
1990-01-01
Abstract
Different approaches to the title ring systems were examined, based on the cleavage of the N–O bond in the isoxazolopyridine-4-thiols (3) and (4) which afforded the hydroxy derivatives (6) and (7), respectively, in moderate to good yields. 3-Methylisothiazolo-[5,4-b]- and -[4,5-c]-pyridine (11) and (18), as well as several functionalized derivatives, were easily obtained from these key intermediates through the corresponding 4,6-dichloroisothiazolopyridines (10) and (17).
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https://hdl.handle.net/11365/6830
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