BACKGROUND: Epileptic syndromes with continuous spikes-waves during sleep (CSWS) represent a wide spectrum of epileptic disorders having CSWS as a common EEG-feature. Defined therapeutic strategies are still lacking. We evaluated the efficacy of lacosamide add-on therapy on the EEG, behavior, and cognition in children with CSWS. MATERIAL AND METHODS: Eight children with CSWS refractory to other conventional antiepileptic drugs were included in the study. A 24-h EEG recording was performed at 6-month-interval in all patients. The spike-wave index (SWI) was obtained in each 24-h EEG recording. Neuropsychological data were obtained before lacosamide introduction and after a minimum of 12 months of therapy. RESULTS: After a 6-month period of therapy, 75% of patients was defined as responder, 12.5% as partial responder and another 12.5% as non-responder. In particular, 24-h EEG normalized in 3 cases (37%). After a minimum of 12 months, 24-h EEG normalized in another patient while two patients showed electroclinical relapses. A total of 62.5% of patients was therefore defined as responder. Neuropsychological functions slightly improved in 25% of patients. CONCLUSION: Although further studies are needed to validate our observations, this study suggests that lacosamide add-on therapy may be safe and effective in children affected by CSWS.

Grosso, S., Parisi, P., Giordano, L., di Bartolo, R., Balestri, P. (2014). Lacosamide efficacy in epileptic syndromes with continuous spike and waves during slow sleep (CSWS). EPILEPSY RESEARCH, 108(9), 1604-1608 [10.1016/j.eplepsyres.2014.08.021].

Lacosamide efficacy in epileptic syndromes with continuous spike and waves during slow sleep (CSWS)

Grosso, Salvatore;di Bartolo, Rosanna;Balestri, Paolo
2014-01-01

Abstract

BACKGROUND: Epileptic syndromes with continuous spikes-waves during sleep (CSWS) represent a wide spectrum of epileptic disorders having CSWS as a common EEG-feature. Defined therapeutic strategies are still lacking. We evaluated the efficacy of lacosamide add-on therapy on the EEG, behavior, and cognition in children with CSWS. MATERIAL AND METHODS: Eight children with CSWS refractory to other conventional antiepileptic drugs were included in the study. A 24-h EEG recording was performed at 6-month-interval in all patients. The spike-wave index (SWI) was obtained in each 24-h EEG recording. Neuropsychological data were obtained before lacosamide introduction and after a minimum of 12 months of therapy. RESULTS: After a 6-month period of therapy, 75% of patients was defined as responder, 12.5% as partial responder and another 12.5% as non-responder. In particular, 24-h EEG normalized in 3 cases (37%). After a minimum of 12 months, 24-h EEG normalized in another patient while two patients showed electroclinical relapses. A total of 62.5% of patients was therefore defined as responder. Neuropsychological functions slightly improved in 25% of patients. CONCLUSION: Although further studies are needed to validate our observations, this study suggests that lacosamide add-on therapy may be safe and effective in children affected by CSWS.
2014
Grosso, S., Parisi, P., Giordano, L., di Bartolo, R., Balestri, P. (2014). Lacosamide efficacy in epileptic syndromes with continuous spike and waves during slow sleep (CSWS). EPILEPSY RESEARCH, 108(9), 1604-1608 [10.1016/j.eplepsyres.2014.08.021].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/50008
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