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The modulation of the HDL receptor scavenger receptor B1 (SRB1) was evaluated in skin fibroblasts isolated from patients with Rett syndrome (RTT), a genetic form of infantile autism. Patients showed an altered plasma lipid profile, while their skin fibroblasts showed a dramatic reduction in SRB1 (immunogold, Western blot and immunohistochemistry). The decreased SRB1 levels were demonstrated to be the consequence of its binding with 4-hydroxy-2-nonenal (4HNE), a product of lipid peroxidation, and its increased ubiquitination. Our findings show for the first time a loss of SRB1 in RTT cells and its relationship with a chronic oxidative stress status. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Sticozzi, C., Belmonte, G., Pecorelli, A., Cervellati, F., Leoncini, S., Signorini, C., et al. (2013). Scavenger receptor B1 post-translational modifications in Rett syndrome. FEBS LETTERS, 587(14), 2199-2204 [10.1016/j.febslet.2013.05.042].

Scavenger receptor B1 post-translational modifications in Rett syndrome

Sticozzi, C.;Leoncini, S.;Signorini, C.;Ciccoli, L.;
2013-01-01

Abstract

The modulation of the HDL receptor scavenger receptor B1 (SRB1) was evaluated in skin fibroblasts isolated from patients with Rett syndrome (RTT), a genetic form of infantile autism. Patients showed an altered plasma lipid profile, while their skin fibroblasts showed a dramatic reduction in SRB1 (immunogold, Western blot and immunohistochemistry). The decreased SRB1 levels were demonstrated to be the consequence of its binding with 4-hydroxy-2-nonenal (4HNE), a product of lipid peroxidation, and its increased ubiquitination. Our findings show for the first time a loss of SRB1 in RTT cells and its relationship with a chronic oxidative stress status. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
2013
FEBS LETTERS
Sticozzi, C., Belmonte, G., Pecorelli, A., Cervellati, F., Leoncini, S., Signorini, C., et al. (2013). Scavenger receptor B1 post-translational modifications in Rett syndrome. FEBS LETTERS, 587(14), 2199-2204 [10.1016/j.febslet.2013.05.042].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/47868
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