In the present work, using Congo Red (CR) birefringence and immunofluorescence, we report for the first time the presence of SAA-amyloidosis in the stenotic aortic valve of an alkaptonuric patient. Light microscopy revealed a co-localization of ochronotic pigment and SAA-amyloid, tissue calcification, lipid oxidation, inflammation, and tissue degeneration.
Millucci, L., Ghezzi, L., Braconi, D., Laschi, M., Geminiani, M., Amato, L., et al. (2014). Secondary amyloidosis in an alkaptonuric aortic valve. INTERNATIONAL JOURNAL OF CARDIOLOGY, 172(1), e121-e123 [10.1016/j.ijcard.2013.12.117].
Secondary amyloidosis in an alkaptonuric aortic valve
Millucci, Lia;Ghezzi, Lorenzo;Braconi, Daniela;Laschi, Marcella;Geminiani, Michela;Amato, Loredana;Orlandini, Maurizio;Bernardini, Giulia;Santucci, Annalisa
2014-01-01
Abstract
In the present work, using Congo Red (CR) birefringence and immunofluorescence, we report for the first time the presence of SAA-amyloidosis in the stenotic aortic valve of an alkaptonuric patient. Light microscopy revealed a co-localization of ochronotic pigment and SAA-amyloid, tissue calcification, lipid oxidation, inflammation, and tissue degeneration.
| File | Dimensione | Formato | |
|---|---|---|---|
|
Millucci et al IJCA 2014.pdf
non disponibili
Tipologia:
Post-print
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
503.14 kB
Formato
Adobe PDF
|
503.14 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/46271
Attenzione
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo