A partially hydrolyzed ethylene/vinyl acetate (EVA) copolymer was modified through the covalent binding of a heparin-complexing polymer, in order to improve its blood compatibility. Two different heparinizable polymeric materials (EVAPA I and II) were obtained by a two-step reaction between an ethylene/vinyl alcohol/vinyl acetate (EVALVA) terpolymer and a poly-(amido-amine) (N2LL) using either hexamethylene diisocyanate (HMDI) or 1,1'-carbonyldimidazole (CDI) as bifunctional agents. EVALVA terpolymer was prepared by a homogeneous saponification process, and the percentage of hydrolysis was determined by an analytical method. EVAPA I and II syntheses were followed by FT-IR/ATR (Fourier Transform Infrared/Attenuated Total Reflection) spectroscopy.
R., B., Benvenuti, M., Magnani, A., F., T. (1992). Synthesis of two novel heparinizable polymeric materials starting from an ethylene/vinyl alcohol/vinyl acetate terpolymer. DIE MAKROMOLEKULARE CHEMIE, 193(12), 2979-2988.
Synthesis of two novel heparinizable polymeric materials starting from an ethylene/vinyl alcohol/vinyl acetate terpolymer
BENVENUTI, MANUELA;MAGNANI, AGNESE;
1992-01-01
Abstract
A partially hydrolyzed ethylene/vinyl acetate (EVA) copolymer was modified through the covalent binding of a heparin-complexing polymer, in order to improve its blood compatibility. Two different heparinizable polymeric materials (EVAPA I and II) were obtained by a two-step reaction between an ethylene/vinyl alcohol/vinyl acetate (EVALVA) terpolymer and a poly-(amido-amine) (N2LL) using either hexamethylene diisocyanate (HMDI) or 1,1'-carbonyldimidazole (CDI) as bifunctional agents. EVALVA terpolymer was prepared by a homogeneous saponification process, and the percentage of hydrolysis was determined by an analytical method. EVAPA I and II syntheses were followed by FT-IR/ATR (Fourier Transform Infrared/Attenuated Total Reflection) spectroscopy.
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https://hdl.handle.net/11365/41312
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