A number of pyruvic acid, methylpyruvate and pyruvic carboxaldehyde 2-quinolylhydrazones have been synthesized. Some bis-2-quinolylhydrazones were also obtained during the reaction with pyruvic carboxaldehyde. All these compounds have been evaluated for cytotoxicity and most display a significant in vitro activity against a variety of cell lines.
Savini, L., Massarelli, P., Chiasserini, L., Sega, A., Pellerano, C., Barzi, A., et al. (1995). Chelating agents as potential antitumorals. 2-quinolylhydrazones and bis-2-quinolylhydrazones. I. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 30(7-8), 547-552 [10.1016/0223-5234(96)88268-7].
Chelating agents as potential antitumorals. 2-quinolylhydrazones and bis-2-quinolylhydrazones. I
SAVINI, LUISA;MASSARELLI, PAOLA;CHIASSERINI, LUISA;SEGA, ALESSANDRO;PELLERANO, CESARE;
1995-01-01
Abstract
A number of pyruvic acid, methylpyruvate and pyruvic carboxaldehyde 2-quinolylhydrazones have been synthesized. Some bis-2-quinolylhydrazones were also obtained during the reaction with pyruvic carboxaldehyde. All these compounds have been evaluated for cytotoxicity and most display a significant in vitro activity against a variety of cell lines.
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https://hdl.handle.net/11365/403123
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