Tridentate chelating agents, as potential antitumor agents, were prepared by condensing 2-quinolylhydrazines, 2-pyridylhydrazine and 2-benzothiazolylhydrazine with pyridine-2-aldehyde, 6-methylpyridine-2-aldehyde, 2-acetylpyridine and 2-benzoylpyridine. All compounds were tested against Lymphocytic leukemia P388. The active pyridine-2-aldehyde-4-methyl-2-quinolylhydrazone [1-(4'-methyl-2'-quinolyl)-3-(2'-pyridyl)-1,2-diaza-2-propene] (I d) was also tested against other experimental tumors and proved inactive.
Pellerano, C., Savini, L., Massarelli, P. (1985). Tridentate N-N-N chelating systems as potential antitumor agents [Sistemi chelanti tridentati N*-N*-N* quali potenziali agenti antitumorali]. IL FARMACO. EDIZIONE SCIENTIFICA, 40(9), 645-654.
Tridentate N-N-N chelating systems as potential antitumor agents [Sistemi chelanti tridentati N*-N*-N* quali potenziali agenti antitumorali]
PELLERANO, C.
;SAVINI, L.;MASSARELLI, P.Membro del Collaboration Group
1985-01-01
Abstract
Tridentate chelating agents, as potential antitumor agents, were prepared by condensing 2-quinolylhydrazines, 2-pyridylhydrazine and 2-benzothiazolylhydrazine with pyridine-2-aldehyde, 6-methylpyridine-2-aldehyde, 2-acetylpyridine and 2-benzoylpyridine. All compounds were tested against Lymphocytic leukemia P388. The active pyridine-2-aldehyde-4-methyl-2-quinolylhydrazone [1-(4'-methyl-2'-quinolyl)-3-(2'-pyridyl)-1,2-diaza-2-propene] (I d) was also tested against other experimental tumors and proved inactive.
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https://hdl.handle.net/11365/402136