Several 1-[quinolyl(4)]-1,2,3-triazoles were synthesized by 1,3-dipolar cycloaddition of 4-azidoquinolines with activated methylene compounds. The synthesized compounds, tested for antiinflammatory and analgesic activities, resulted moderately active as antiinflammatories, but with a very interesting analgesic activity, sometimes higher than that of indomethacin, used as reference drug. Some of the triazole derivatives were evaluated also as antimicrobial, but none of them exhibited activity.

Savini, L., Massarelli, P., Chiasserini, L., Pellerano, C., & Bruni, G. (1994). New 1-[quinolyl(4)]-1,2,3-triazoles: synthesis and evaluation of antiinflammatory and analgesic properties. II. IL FARMACO, 49(10), 633-639.

New 1-[quinolyl(4)]-1,2,3-triazoles: synthesis and evaluation of antiinflammatory and analgesic properties. II

SAVINI, LUISA;MASSARELLI, PAOLA;CHIASSERINI, LUISA;PELLERANO, CESARE;BRUNI, GIANCARLO
1994

Abstract

Several 1-[quinolyl(4)]-1,2,3-triazoles were synthesized by 1,3-dipolar cycloaddition of 4-azidoquinolines with activated methylene compounds. The synthesized compounds, tested for antiinflammatory and analgesic activities, resulted moderately active as antiinflammatories, but with a very interesting analgesic activity, sometimes higher than that of indomethacin, used as reference drug. Some of the triazole derivatives were evaluated also as antimicrobial, but none of them exhibited activity.
Savini, L., Massarelli, P., Chiasserini, L., Pellerano, C., & Bruni, G. (1994). New 1-[quinolyl(4)]-1,2,3-triazoles: synthesis and evaluation of antiinflammatory and analgesic properties. II. IL FARMACO, 49(10), 633-639.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/402135
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