Purine nucleotides were studied in human peripheral blood lymphocytes from normal subjects and patients with chronic B-cell lymphocytic leukemia (B-CLL). Nucleotide content was determined by high performance liquid chromatography (HPLC). The overall rate of purine nucleotide synthesis was measured following the incorporation of 14C-formate into the nucleotides of a lymphocytic suspension. Results indicate a substantially reduced rate of purine nucleotide metabolism.
Tabucchi, A., Carlucci, F., Leoncini, R., Vannoni, D., Consolmagno, E., Marinello, E., et al. (1995). Purine nucleotide metabolism in lymphocytes of B-cell chronic lymphocytic leukemia patients. BIOMÉDECINE & PHARMACOTHÉRAPIE, 49(3), 141-144 [10.1016/0753-3322(96)82607-2].
Purine nucleotide metabolism in lymphocytes of B-cell chronic lymphocytic leukemia patients
Tabucchi A.;Carlucci F.;Leoncini R.;Vannoni D.;Marinello E.;Pizzichini M.;Pagani R.
1995-01-01
Abstract
Purine nucleotides were studied in human peripheral blood lymphocytes from normal subjects and patients with chronic B-cell lymphocytic leukemia (B-CLL). Nucleotide content was determined by high performance liquid chromatography (HPLC). The overall rate of purine nucleotide synthesis was measured following the incorporation of 14C-formate into the nucleotides of a lymphocytic suspension. Results indicate a substantially reduced rate of purine nucleotide metabolism.
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https://hdl.handle.net/11365/37389
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