The peripheral secretion of endogenous opioids was studied in 10 women with restrictive anorexia nervosa and 10 age- and sex-matched healthy controls. The circadian rhythm of beta-endorphin (beta-EP) and beta-lipotropin (beta-LPH), and their responses to the administration of corticotropin releasing hormone (CRH, 1 micrograms/kg body weight, i.v.), clonidine (150 microgram, i.v.), domperidone (10 mg, i.v.), and 5-hydroxytryptophan (5-HTP, 200 mg, p.o.) were examined in patients and controls. The results revealed increased nocturnal secretion of beta-EP and diurnal-nocturnal secretion of beta-LPH with loss of circadian rhythmicity of both peptides, normal response to CRH stimulation, blunted response to clonidine and domperidine, and normal beta-EP and blunted beta-LPH response to 5-HTP stimulation. The data suggest a complex alteration of peripheral opioids and of central aminergic mechanisms that regulate proopiomelanocortin-derived peptide secretion and eating behavior.
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|Titolo:||Peripheral opioid secretory pattern in anorexia nervosa.|
|Citazione:||Brambilla, F., Ferrari, E., Petraglia, F., Facchinetti, F., Catalano, M., & Genazzani, A.r. (1991). Peripheral opioid secretory pattern in anorexia nervosa. PSYCHIATRY RESEARCH, 39(2), 115-127.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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