The arrhythmogenicity of anti-Ro/SSA antibodies for the foetal heart and their crucial role in the development of congenital heart block is now well established, representing a paradigmatic model of passively acquired autoimmunity. Recently, intriguing data suggest that also the adult heart may represent a possible target of anti-Ro/SSA antibody-mediated autoimmune injury. The prolongation of the QTc interval, possibly resulting from a direct inhibitory interaction between the anti-Ro/SSA antibodies and the potassium current I(Kr) in the heart seems the abnormality more frequently observed in adults with anti-Ro/SSA-positive CTD. Although the possibility that anti-Ro/SSA positivity may be considered a risk factor for arrhythmic sudden death in adults has not been demonstrated as yet, preliminary data suggest a relationship among anti-Ro/SSA antibodies, QTc prolongation, and the prevalence of ventricular arrhythmias, also life threatening, in adult patients.

Lazzerini, P.E., Capecchi, P.L., Acampa, M., Selvi, E., Guideri, F., Bisogno, S., et al. (2009). Arrhythmogenic effects of anti-Ro/SSA antibodies on theadult heart: more than expected?. AUTOIMMUNITY REVIEWS, 9(1), 40-44 [10.1016/j.autrev.2009.03.002].

Arrhythmogenic effects of anti-Ro/SSA antibodies on theadult heart: more than expected?

LAZZERINI, PIETRO ENEA;CAPECCHI, PIER LEOPOLDO;GUIDERI, FRANCESCA;GALEAZZI, MAURO;LAGHI PASINI, FRANCO
2009-01-01

Abstract

The arrhythmogenicity of anti-Ro/SSA antibodies for the foetal heart and their crucial role in the development of congenital heart block is now well established, representing a paradigmatic model of passively acquired autoimmunity. Recently, intriguing data suggest that also the adult heart may represent a possible target of anti-Ro/SSA antibody-mediated autoimmune injury. The prolongation of the QTc interval, possibly resulting from a direct inhibitory interaction between the anti-Ro/SSA antibodies and the potassium current I(Kr) in the heart seems the abnormality more frequently observed in adults with anti-Ro/SSA-positive CTD. Although the possibility that anti-Ro/SSA positivity may be considered a risk factor for arrhythmic sudden death in adults has not been demonstrated as yet, preliminary data suggest a relationship among anti-Ro/SSA antibodies, QTc prolongation, and the prevalence of ventricular arrhythmias, also life threatening, in adult patients.
Lazzerini, P.E., Capecchi, P.L., Acampa, M., Selvi, E., Guideri, F., Bisogno, S., et al. (2009). Arrhythmogenic effects of anti-Ro/SSA antibodies on theadult heart: more than expected?. AUTOIMMUNITY REVIEWS, 9(1), 40-44 [10.1016/j.autrev.2009.03.002].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/35992
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