The arrhythmogenicity of anti-Ro/SSA antibodies for the foetal heart and their crucial role in the development of congenital heart block is now well established, representing a paradigmatic model of passively acquired autoimmunity. Recently, intriguing data suggest that also the adult heart may represent a possible target of anti-Ro/SSA antibody-mediated autoimmune injury. The prolongation of the QTc interval, possibly resulting from a direct inhibitory interaction between the anti-Ro/SSA antibodies and the potassium current I(Kr) in the heart seems the abnormality more frequently observed in adults with anti-Ro/SSA-positive CTD. Although the possibility that anti-Ro/SSA positivity may be considered a risk factor for arrhythmic sudden death in adults has not been demonstrated as yet, preliminary data suggest a relationship among anti-Ro/SSA antibodies, QTc prolongation, and the prevalence of ventricular arrhythmias, also life threatening, in adult patients.
|Titolo:||Arrhythmogenic effects of anti-Ro/SSA antibodies on theadult heart: more than expected?|
|Citazione:||Lazzerini, P.E., Capecchi, P.L., Acampa, M., Selvi, E., Guideri, F., Bisogno, S., et al. (2009). Arrhythmogenic effects of anti-Ro/SSA antibodies on theadult heart: more than expected?. AUTOIMMUNITY REVIEWS, 9(1), 40-44.|
|Appare nelle tipologie:||1.1 Articolo in rivista|