The synthesis of simple, non-sugar glycosaminoglycan (GAG) mimics has been achieved and the analogues evaluated for their ability to inhibit the activation of the MET receptor by hepatocyte growth factor/scatter factor (HGF/SF).
Raiber, E.A., Wilkinson, J.A., Manetti, F., Botta, M., Deakin, J., Gallagher, J., et al. (2007). Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 17(22), 6321-6325 [10.1016/j.bmcl.2007.08.074].
Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation
MANETTI, FABRIZIO;BOTTA, MAURIZIO;
2007-01-01
Abstract
The synthesis of simple, non-sugar glycosaminoglycan (GAG) mimics has been achieved and the analogues evaluated for their ability to inhibit the activation of the MET receptor by hepatocyte growth factor/scatter factor (HGF/SF).
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