Three racemic esters based on the 1,5-diarylpyrrole structure, which proved to be highly selective COX-2 inhibitors endowed with an appreciable anti-inflammatory activity in some animal models, were subjected to chiral resolution. Their absolute configurations were assigned by comparison of the CD spectrum measured on-line with a HPLC-CD detector, with that calculated by means of a TDDFT method. © 2007 Elsevier Ltd. All rights reserved.
Di Bari, L., Pescitelli, G., Salvatori, P., Rovini, M., Anzini, M., Cappelli, A., et al. (2006). Synthesis, Resolution, and Absolute Configuration of Two Novel and Selective Cyclooxygenase-2 Inhibitors Based on 1,5-Diarylpyrrole Structure. TETRAHEDRON-ASYMMETRY, 17(24), 3430-3436 [10.1016/j.tetasy.2006.12.019].
Synthesis, Resolution, and Absolute Configuration of Two Novel and Selective Cyclooxygenase-2 Inhibitors Based on 1,5-Diarylpyrrole Structure
Anzini, Maurizio;Cappelli, Andrea;Vomero, Salvatore
2006-01-01
Abstract
Three racemic esters based on the 1,5-diarylpyrrole structure, which proved to be highly selective COX-2 inhibitors endowed with an appreciable anti-inflammatory activity in some animal models, were subjected to chiral resolution. Their absolute configurations were assigned by comparison of the CD spectrum measured on-line with a HPLC-CD detector, with that calculated by means of a TDDFT method. © 2007 Elsevier Ltd. All rights reserved.
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https://hdl.handle.net/11365/3494
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