We evaluated the CSF levels of beta-lipotropin (beta-LPH), beta-endorphin (beta-EP) and ACTH, which are three neuropeptides expressed by the same gene encoding for pro-opiomelanocortin, in various groups of demented patients including degenerative (presenile and senile Alzheimer-type dementia, ATD) and vascular (MID) forms. Twelve sex- and age-matched subjects were taken as controls. Our data indicate that ACTH levels are significantly reduced both in ATD and MID patients, while beta-EP and beta-LPH are significantly reduced only in ATD. The low CSF ACTH levels can be considered typical of all demented processes (both degenerative and vascular), while the reduction of beta-EP and beta-LPH in CSF could be due to a degenerative process of CNS.
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|Titolo:||Aging brain and dementias: changes in central opioids.|
|Citazione:||Nappi, G., Sinforiani, E., Martignoni, E., Petraglia, F., Facchinetti, F., Rossi, F., et al. (1988). Aging brain and dementias: changes in central opioids. EUROPEAN NEUROLOGY, 28(4), 217-220.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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