In 8 patients, beta-lipotropin (beta-LPH), beta-endorphin (beta-EP), ACTH, protein and chloride concentrations were measured in cerebrospinal fluid (CSF) samples obtained simultaneously from the lumbar space and lateral ventricle. Albumin and IgG levels were significantly higher in lumbar than in ventricular CSF samples while no craniocaudal gradient was observed for neuropeptide concentrations. The importance of molecular weight in determining such a regional distribution is supported also by the similar lumbar and ventricular levels of chlorides. These data would validate the CSF approach through lumbar puncture as a tool for exploring neuropeptides in the central nervous system.

Facchinetti, F., Petraglia, F., Cicero, S., Nappi, G., Valentini, M., & Genazzani, A.R. (1987). No gradient exists between lumbar and ventricular cerebrospinal fluid beta-endorphin. NEUROSCIENCE LETTERS, 77(3), 349-352 [10.1016/0304-3940(87)90526-X].

No gradient exists between lumbar and ventricular cerebrospinal fluid beta-endorphin

Petraglia, F.;
1987

Abstract

In 8 patients, beta-lipotropin (beta-LPH), beta-endorphin (beta-EP), ACTH, protein and chloride concentrations were measured in cerebrospinal fluid (CSF) samples obtained simultaneously from the lumbar space and lateral ventricle. Albumin and IgG levels were significantly higher in lumbar than in ventricular CSF samples while no craniocaudal gradient was observed for neuropeptide concentrations. The importance of molecular weight in determining such a regional distribution is supported also by the similar lumbar and ventricular levels of chlorides. These data would validate the CSF approach through lumbar puncture as a tool for exploring neuropeptides in the central nervous system.
Facchinetti, F., Petraglia, F., Cicero, S., Nappi, G., Valentini, M., & Genazzani, A.R. (1987). No gradient exists between lumbar and ventricular cerebrospinal fluid beta-endorphin. NEUROSCIENCE LETTERS, 77(3), 349-352 [10.1016/0304-3940(87)90526-X].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/33522
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo