Human natural interferon-beta (HuIFN-beta) was administered through different routes (intravenous [i.v.], intramuscular [i.m.], and subcutaneous [s.c.]) and its distribution in lymph and plasma was evaluated. After i.v. (bolus) administration the lymph/plasma ratio was about 0.35 but it significantly increased (11-fold) after i.m. administration. Addition of human albumin (ALB) to the IFN solution did not favor IFN absorption through the lymphatics. On the other hand, addition of ALB improved IFN absorption through the lymphatics after s.c. administration. These results are interesting because they clarify why IFN-beta can exert immunomodulatory activities in spite of very low plasma levels.

Bocci, V., Pessina, G.p., Ricci, L., Muscettola, M., Valeri, A. (1988). The lymphatic route. V. Distribution of human natural nterferon-beta in rabbit plasma and lymph. JOURNAL OF INTERFERON RESEARCH, 8(5), 633-640.

The lymphatic route. V. Distribution of human natural nterferon-beta in rabbit plasma and lymph.

Pessina GP;Ricci L;Muscettola M;Valeri A
1988-01-01

Abstract

Human natural interferon-beta (HuIFN-beta) was administered through different routes (intravenous [i.v.], intramuscular [i.m.], and subcutaneous [s.c.]) and its distribution in lymph and plasma was evaluated. After i.v. (bolus) administration the lymph/plasma ratio was about 0.35 but it significantly increased (11-fold) after i.m. administration. Addition of human albumin (ALB) to the IFN solution did not favor IFN absorption through the lymphatics. On the other hand, addition of ALB improved IFN absorption through the lymphatics after s.c. administration. These results are interesting because they clarify why IFN-beta can exert immunomodulatory activities in spite of very low plasma levels.
Bocci, V., Pessina, G.p., Ricci, L., Muscettola, M., Valeri, A. (1988). The lymphatic route. V. Distribution of human natural nterferon-beta in rabbit plasma and lymph. JOURNAL OF INTERFERON RESEARCH, 8(5), 633-640.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/31963
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo