Since ACTH and the opioids display opposite effects on experimentally-induced seizures, cerebrospinal fluid (CSF) levels of ACTH and β-endorphin (β-EP) were measured in 6 children (4-8 months) affected by infantile spasms with hypsarhythmia, an idiopathic early onset encephalopathy, and in 8 age-matched controls. β-EP levels in the patients (76.3±14.7 fmol/ml, M±SD) did not differ from those in controls (109.8±42.7) while babies with epileptic encephalopathy showed reduced ACTH levels in the CSF (3.8±1.5) as compared to controls (9.0±3.7, p<0.01). This resulted in an increased β-EP/ACTH ratio. Another patient previously treated with ACTH showed a normal CSF level of ACTH (9.0) with a normal β-EP/ACTH ratio while in clinical and EEG remission. These results are consistent with the hypothesis that some infantile seizures unrelated to brain injuries could originate from an ACTH deficiency at central level and/or an imbalance of neuropeptidergic pathways. © 1985.

Facchinetti, F., Nalin, A., Petraglia, F., Galli, V., Genazzani, A.R. (1985). Reduced ACTH, while normal beta-endorphin CSF levels in early epileptic encephalopathies. PEPTIDES, 6(1), 31-33 [10.1016/0196-9781(85)90072-5].

Reduced ACTH, while normal beta-endorphin CSF levels in early epileptic encephalopathies

Petraglia, F.;
1985-01-01

Abstract

Since ACTH and the opioids display opposite effects on experimentally-induced seizures, cerebrospinal fluid (CSF) levels of ACTH and β-endorphin (β-EP) were measured in 6 children (4-8 months) affected by infantile spasms with hypsarhythmia, an idiopathic early onset encephalopathy, and in 8 age-matched controls. β-EP levels in the patients (76.3±14.7 fmol/ml, M±SD) did not differ from those in controls (109.8±42.7) while babies with epileptic encephalopathy showed reduced ACTH levels in the CSF (3.8±1.5) as compared to controls (9.0±3.7, p<0.01). This resulted in an increased β-EP/ACTH ratio. Another patient previously treated with ACTH showed a normal CSF level of ACTH (9.0) with a normal β-EP/ACTH ratio while in clinical and EEG remission. These results are consistent with the hypothesis that some infantile seizures unrelated to brain injuries could originate from an ACTH deficiency at central level and/or an imbalance of neuropeptidergic pathways. © 1985.
1985
Facchinetti, F., Nalin, A., Petraglia, F., Galli, V., Genazzani, A.R. (1985). Reduced ACTH, while normal beta-endorphin CSF levels in early epileptic encephalopathies. PEPTIDES, 6(1), 31-33 [10.1016/0196-9781(85)90072-5].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/31891
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