Intravenous administration of poly ICLC in rabbits yields very high plasma interferon (IFN) levels; dosages from 250 to 1000 micrograms/kg body weight are very toxic. Subcutaneous administration of poly ICLC together with a high concentration of human serum albumin potentiates the inducer activity in comparison to poly ICLC in saline. Finally, a dosage of 50 micrograms of poly ICLC in 12% serum albumin is more effective as an IFN inducer than other dosages.
Pessina, G.p., Muscettola, M., Ricci, L., Bocci, V. (1989). Enhanced induction of plasma interferon after subcutaneous administration in rabbits of poly ICLC with albumin. JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS, 3(3), 118-121.
Enhanced induction of plasma interferon after subcutaneous administration in rabbits of poly ICLC with albumin
Pessina GP;Muscettola M;Ricci L;
1989-01-01
Abstract
Intravenous administration of poly ICLC in rabbits yields very high plasma interferon (IFN) levels; dosages from 250 to 1000 micrograms/kg body weight are very toxic. Subcutaneous administration of poly ICLC together with a high concentration of human serum albumin potentiates the inducer activity in comparison to poly ICLC in saline. Finally, a dosage of 50 micrograms of poly ICLC in 12% serum albumin is more effective as an IFN inducer than other dosages.
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https://hdl.handle.net/11365/31882