The renal handling of human interferon-alpha has been evaluated by using an isolated and perfused rabbit kidney. IFN-alpha disappears from plasma with a t1/2 of 81 min and the fractional turnover rate is 0.84%/min. About 47 molecules of IFN-alpha are filtrated with 100 molecules of creatinine but most of the IFN is absorbed by tubular cells. This is the first report showing that human IFN-alpha is filtrated by the kidney, largely absorbed, most probably catabolized within tubular epithelium and excreted in negligible amounts with the urine.

Bocci, V., Pacini, A., Muscettola, M., Ricci, L., Pessina, G.p., Santiano, M., et al. (1981). Renal filtration, absorption and catabolism of human alpha interferon. JOURNAL OF INTERFERON RESEARCH, 1(3), 347-352.

Renal filtration, absorption and catabolism of human alpha interferon

Pacini A;Muscettola M;Ricci L;Pessina GP;
1981-01-01

Abstract

The renal handling of human interferon-alpha has been evaluated by using an isolated and perfused rabbit kidney. IFN-alpha disappears from plasma with a t1/2 of 81 min and the fractional turnover rate is 0.84%/min. About 47 molecules of IFN-alpha are filtrated with 100 molecules of creatinine but most of the IFN is absorbed by tubular cells. This is the first report showing that human IFN-alpha is filtrated by the kidney, largely absorbed, most probably catabolized within tubular epithelium and excreted in negligible amounts with the urine.
Bocci, V., Pacini, A., Muscettola, M., Ricci, L., Pessina, G.p., Santiano, M., et al. (1981). Renal filtration, absorption and catabolism of human alpha interferon. JOURNAL OF INTERFERON RESEARCH, 1(3), 347-352.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/31485
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo