The renal handling of human interferon-alpha has been evaluated by using an isolated and perfused rabbit kidney. IFN-alpha disappears from plasma with a t1/2 of 81 min and the fractional turnover rate is 0.84%/min. About 47 molecules of IFN-alpha are filtrated with 100 molecules of creatinine but most of the IFN is absorbed by tubular cells. This is the first report showing that human IFN-alpha is filtrated by the kidney, largely absorbed, most probably catabolized within tubular epithelium and excreted in negligible amounts with the urine.
Bocci, V., Pacini, A., Muscettola, M., Ricci, L., Pessina, G.P., Santiano, M., et al. (1981). Renal filtration, absorption and catabolism of human alpha interferon. JOURNAL OF INTERFERON RESEARCH, 1(3), 347-352 [10.1089/jir.1981.1.347].
Renal filtration, absorption and catabolism of human alpha interferon
Bocci, V.;Pacini, A.;Muscettola, M.;Ricci, L.;Pessina, G. P.;
1981-01-01
Abstract
The renal handling of human interferon-alpha has been evaluated by using an isolated and perfused rabbit kidney. IFN-alpha disappears from plasma with a t1/2 of 81 min and the fractional turnover rate is 0.84%/min. About 47 molecules of IFN-alpha are filtrated with 100 molecules of creatinine but most of the IFN is absorbed by tubular cells. This is the first report showing that human IFN-alpha is filtrated by the kidney, largely absorbed, most probably catabolized within tubular epithelium and excreted in negligible amounts with the urine.
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https://hdl.handle.net/11365/31485
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