The renal handling of human interferon-alpha has been evaluated by using an isolated and perfused rabbit kidney. IFN-alpha disappears from plasma with a t1/2 of 81 min and the fractional turnover rate is 0.84%/min. About 47 molecules of IFN-alpha are filtrated with 100 molecules of creatinine but most of the IFN is absorbed by tubular cells. This is the first report showing that human IFN-alpha is filtrated by the kidney, largely absorbed, most probably catabolized within tubular epithelium and excreted in negligible amounts with the urine.
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|Titolo:||Renal filtration, absorption and catabolism of human alpha interferon|
|Citazione:||Bocci, V., Pacini, A., Muscettola, M., Ricci, L., Pessina, G.p., Santiano, M., et al. (1981). Renal filtration, absorption and catabolism of human alpha interferon. JOURNAL OF INTERFERON RESEARCH, 1(3), 347-352.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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