New 5-chloro-6-substituted-uracil derivs. have been prepd. by microwave assisted-synthesis and tested in vitro as thymidine phosphorylase inhibitors. One of these compds. showed potent inhibitory activity, with an IC50 value in the submicromolar range. The biol. activity of the new compds. is discussed in terms of structure-activity relationship.
Corelli, F., Botta, M., Lossani, A., Pasquini, S., Spadari, S., Focher, F. (2004). Microwave-assisted synthesis and biological evaluation of novel uracil derivatives inhibiting human thymidine phosphorylase. IL FARMACO, 59(12), 987-992 [10.1016/j.farmac.2004.08.007].
Microwave-assisted synthesis and biological evaluation of novel uracil derivatives inhibiting human thymidine phosphorylase
Corelli, Federico;Botta, Maurizio;Pasquini, Serena;
2004-01-01
Abstract
New 5-chloro-6-substituted-uracil derivs. have been prepd. by microwave assisted-synthesis and tested in vitro as thymidine phosphorylase inhibitors. One of these compds. showed potent inhibitory activity, with an IC50 value in the submicromolar range. The biol. activity of the new compds. is discussed in terms of structure-activity relationship.
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https://hdl.handle.net/11365/31417
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