Intravenous administration of PPD into BCG-primed rabbits results in the release of IFN into the circulation. Peak interferon titres occur in plasma 1 h after PPD injection, rapidly decline during the following 3 h and depend on the dose of tuberculin administered. Bilateral nephrectomy of BCG-primed rabbits challenged with PPD affects remarkably the disappearance of IFN from the circulation. Characterization of the BCG-PPD-induced IFN shows that it is heat-labile, is almost completely inactivated after dialysis at pH 2 and displays a remarkable cross-species activity, particularly on human cell lines.
Pessina, G.P., Ricci, L., Muscettola, M., Skiftas, S., Lunghetti, G., Bocci, V. (1985). Interferon production in BCG-sensitized rabbits challenged with PPD. IMMUNOLOGY LETTERS, 10(6), 315-318 [10.1016/0165-2478(85)90124-5].
Interferon production in BCG-sensitized rabbits challenged with PPD
Pessina, G. P.;Ricci, L.;Muscettola, M.;Bocci, V.
1985-01-01
Abstract
Intravenous administration of PPD into BCG-primed rabbits results in the release of IFN into the circulation. Peak interferon titres occur in plasma 1 h after PPD injection, rapidly decline during the following 3 h and depend on the dose of tuberculin administered. Bilateral nephrectomy of BCG-primed rabbits challenged with PPD affects remarkably the disappearance of IFN from the circulation. Characterization of the BCG-PPD-induced IFN shows that it is heat-labile, is almost completely inactivated after dialysis at pH 2 and displays a remarkable cross-species activity, particularly on human cell lines.
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https://hdl.handle.net/11365/31381
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