A stereselective synthesis of the title compounds, starting from commercially available amino acids, is described. The absolute stereochemistry of 3a and 3b has been deduced on the basis of H-1 NMR and chemical degradation studies. The formation of only these two isomers has been rationalized in terms of molecular mechanics calculations.
Corelli, F., A., C., D., D., Taddei, M., & Botta, M. (1994). Cyclic Dipeptides - A Stereocontrolled Synthesis of (2s,3r,6r) and (2r,3r,6r)-6-tert-butoxycarbonylamino-3-methoxycarbonyl-2-methyl-5-oxope Rhydro-1,4-thiazepine. TETRAHEDRON-ASYMMETRY, 5, 1469-1472.
Scheda prodotto non validato
Scheda prodotto in fase di analisi da parte dello staff di validazione
Titolo: | Cyclic Dipeptides - A Stereocontrolled Synthesis of (2s,3r,6r) and (2r,3r,6r)-6-tert-butoxycarbonylamino-3-methoxycarbonyl-2-methyl-5-oxope Rhydro-1,4-thiazepine |
Autori: | |
Rivista: | |
Citazione: | Corelli, F., A., C., D., D., Taddei, M., & Botta, M. (1994). Cyclic Dipeptides - A Stereocontrolled Synthesis of (2s,3r,6r) and (2r,3r,6r)-6-tert-butoxycarbonylamino-3-methoxycarbonyl-2-methyl-5-oxope Rhydro-1,4-thiazepine. TETRAHEDRON-ASYMMETRY, 5, 1469-1472. |
Anno: | 1994 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11365/31203