Human recombinant (R) interleukin-2 (IL-2) has been administered through intravenous (i.v.), intramuscular (i.m.) and subcutaneous (s.c.) routes and its distribution in lymph and plasma has been evaluated in rabbits. It has been shown that after i.m. administration of RIL-2 in saline, the lymphokine is preferentially absorbed via lymphatics. A similar result has been obtained after s.c. administration when RIL-2 was injected with a high concentration (12.5%) of human albumin, which acts as a retarder and a promoter of lymphatic absorption. These routes may be valid alternatives to i.v. administration
Bocci, V., Pessina, G.P., Nicoletti, C., Ricci, L. (1990). The lymphatic route. VII. Distribution of recombinant human interleukin-2 in rabbit plasma and lymph. JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS, 4(1), 25-29.
The lymphatic route. VII. Distribution of recombinant human interleukin-2 in rabbit plasma and lymph
Bocci, V.;Pessina, G. P.;Nicoletti, C.;Ricci, L.
1990-01-01
Abstract
Human recombinant (R) interleukin-2 (IL-2) has been administered through intravenous (i.v.), intramuscular (i.m.) and subcutaneous (s.c.) routes and its distribution in lymph and plasma has been evaluated in rabbits. It has been shown that after i.m. administration of RIL-2 in saline, the lymphokine is preferentially absorbed via lymphatics. A similar result has been obtained after s.c. administration when RIL-2 was injected with a high concentration (12.5%) of human albumin, which acts as a retarder and a promoter of lymphatic absorption. These routes may be valid alternatives to i.v. administrationI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/30956
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