Syntheses of four new pyrimidone analogues of the acetylcholinesterase (AChE) inhibitor huperzine A are reported together with the inhibitory potencies of these compounds for foetal bovine calf serum AChE; β-lactone formation followed by a thermal cycloreversion reaction serves as the key step for introduction of the ethylidene appendage of 12 in the stereochemically correct form.
Kozikowski, A.P., Campiani, G., Saxena, A., Doctor, B.P. (1995). Synthesis and acetylcholinesterase inhibitory activity of several pyrimidone analogues of huperzine A. JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, 2, 283-285 [10.1039/c39950000283].
Synthesis and acetylcholinesterase inhibitory activity of several pyrimidone analogues of huperzine A
Campiani, Giuseppe;
1995-01-01
Abstract
Syntheses of four new pyrimidone analogues of the acetylcholinesterase (AChE) inhibitor huperzine A are reported together with the inhibitory potencies of these compounds for foetal bovine calf serum AChE; β-lactone formation followed by a thermal cycloreversion reaction serves as the key step for introduction of the ethylidene appendage of 12 in the stereochemically correct form.
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https://hdl.handle.net/11365/30133
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