A new synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones was developed as a domino alkylation-cyclization of propargyl bromides with thioureas and thiopyrimidinones, resp. Domino reactions were performed under microwave irradn. leading to the desired compds. in a few minutes and high yields.
Castagnolo, D., Pagano, M., Bernardini, M., Botta, M. (2009). Domino alkylation-cyclization reaction of propargyl bromides with thioureas/thiopyrimidinones: a new facile synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones. SYNLETT(13), 2093-2096 [10.1055/s-0029-1217700].
Domino alkylation-cyclization reaction of propargyl bromides with thioureas/thiopyrimidinones: a new facile synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones
Castagnolo, Daniele;Pagano, Mafalda;Bernardini, Martina;Botta, Maurizio
2009-01-01
Abstract
A new synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones was developed as a domino alkylation-cyclization of propargyl bromides with thioureas and thiopyrimidinones, resp. Domino reactions were performed under microwave irradn. leading to the desired compds. in a few minutes and high yields.
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https://hdl.handle.net/11365/30079
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